基本信息
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职业迁徙
个人简介
Current Research and Scholarly Interests
Adaptive Evolution and the Fitness Landscape
When yeast are evolved under various selective pressures in a chemostat, mutations that arise and provide an adaptive advantage will expand within the population. We have pioneered the use of high throughput sequencing to determine the identity of such mutations, as well as to understand the dynamics of the mutations within the populations, and the interactions between the mutations (such as epistasis). Further, we have developed a DNA barcode based lineage tracking system to determine the distribution of fitness effects (DFE) for newly arising beneficial mutations. We have also characterized what we call the genotype-fitness map for beneficial mutations, and have investigated why beneficial mutations provide a positive fitness effect. We are also interested in how beneficial mutations trade-off for different traits, and how those trade-offs constrain adaptive evolution.
研究兴趣
论文共 10 篇作者统计合作学者相似作者
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Weiyi Li,Darach Miller,Xianan Liu,Lorenzo Tosi,Lamia Chkaiban,Han Mei, Po-Hsiang Hung,Biju Parekkadan,Gavin Sherlock,Sasha F Levy
bioRxiv : the preprint server for biology (2023)
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Boris U. Stambuk, Marcelo G. Dario, Julio C. A. Espirito-Santo,Eduarda H. Duval, Jr. Alves- Sergio L.,Carlos A. Rosa,Marcos Antonio de Morais Junior,Barbara Dunn,Gavin Sherlock
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Juliette Martin,Thibault Nidelet,Daniel J Kvitek,Ayme Spor,Dominique De Vienne,Gavin Sherlock,Delphine Sicard, Judith Legrand,Christine Dillmann, Aurelie Bourgais
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