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A broad variety of methods are employed in the lab, including novel sample extraction, chemical derivatization, gas-phase separation, ultra-high resolution mass spectrometry (UHRMS) and ultra-violet photodissociation tandem mass spectrometry (UVPD-MS/MS), to comprehensively identify and quantify changes in protein expression and post translational modifications, or complex lipid abundances, that are associated with the dysregulation of normal cellular function.
Ultimately, the results obtained from these studies can provide critical insights toward improving our understanding of the onset and progression of disease pathogenesis, including in colorectal cancer and neurodegeneration, and may enable the identification of candidate biomarkers for improved disease diagnostic or prognostic monitoring, or novel targets for therapeutic intervention.
Ultimately, the results obtained from these studies can provide critical insights toward improving our understanding of the onset and progression of disease pathogenesis, including in colorectal cancer and neurodegeneration, and may enable the identification of candidate biomarkers for improved disease diagnostic or prognostic monitoring, or novel targets for therapeutic intervention.
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论文共 242 篇作者统计合作学者相似作者
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Michelle S. Miller,Angus D. Cowan,Jason M. Brouwer, Sean T. Smyth,Liuyu Peng,Ahmad Z. Wardak,Rachel T. Uren,Cindy Luo,Michael J. Roy, Sayali Shah, Ziwen Tan,Gavin E. Reid,
The FEBS journal (2024)
Tzong-Hsien Lee,Patrick Charchar,Frances Separovic,Gavin E. Reid,Irene Yarovsky,Marie-Isabel Aguilar
CHEMICAL SCIENCEno. 10 (2024): 3408-3427
International journal of molecular sciencesno. 13 (2023): 10955-10955
Richard G. Lee,Danielle L. Rudler,Samuel A. Raven,Liuyu Peng, Anaelle Chopin,Edward S. X. Moh,Tim McCubbin,Stefan J. Siira, Samuel V. Fagan, Nicholas J. DeBono,Maike Stentenbach, Jasmin Browne,
Biochimica et biophysica acta. Molecular and cell biology of lipidsno. 12 (2023): 159398-159398
HUMAN MOLECULAR GENETICSno. 7 (2023): 1236-1236
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