基本信息
浏览量:5
职业迁徙
个人简介
research focuses on the neurobiology of GI function in health and disease states and uses a variety of experimental approaches including electrophysiology, calcium imaging, immunocytochemistry and molecular biology. The following three different areas of investigation are ongoing at this time:
Altered GI function in multiple sclerosis. In addition to the somatosensory deficits that are typically associated with MS, these individuals frequently suffer from GI disorders, particularly constipation. We are conducting studies in an effort to understand the mechanisms responsible for altered colonic motility in MS. To accomplish this, we are testing the hypothesis that autoantibodies generated as part of the CNS inflammatory response target enteric neuronal and glial proteins leading to alterations in neuro-glial function.
Mucosal 5-HT4 receptors as a therapeutic target. 5-HT4 receptors in the GI tract have been targeted by receptor agonists for the treatment of constipation. In 2013, we discovered that 5-HT4 receptors are extensively expressed in the epithelial layer of the colon, and we found that stimulation of these receptors accelerates motility, decreases visceral pain, increases serotonin release from enterochromaffin cells, degranulates goblet cells, and induces chloride secretion from enterocytes. In 2016, we reported that enema administration of 5-HT4 agonists accelerates recovery from colitis, and increases epithelial proliferation, wound healing and resistance to oxidative stress. We are now interested in testing whether 5-HT4 agonists that specifically target these receptors can accelerate motility and aid in the reversal of colitis.
Modulation of serotonin signaling by probiotics. Serotonin is an important signaling molecule in the brain, in the gastrointestinal tract, and in many other peripheral tissues. We are testing whether serotonin levels can be up- and/or down-regulated by probiotic treatments.
Altered GI function in multiple sclerosis. In addition to the somatosensory deficits that are typically associated with MS, these individuals frequently suffer from GI disorders, particularly constipation. We are conducting studies in an effort to understand the mechanisms responsible for altered colonic motility in MS. To accomplish this, we are testing the hypothesis that autoantibodies generated as part of the CNS inflammatory response target enteric neuronal and glial proteins leading to alterations in neuro-glial function.
Mucosal 5-HT4 receptors as a therapeutic target. 5-HT4 receptors in the GI tract have been targeted by receptor agonists for the treatment of constipation. In 2013, we discovered that 5-HT4 receptors are extensively expressed in the epithelial layer of the colon, and we found that stimulation of these receptors accelerates motility, decreases visceral pain, increases serotonin release from enterochromaffin cells, degranulates goblet cells, and induces chloride secretion from enterocytes. In 2016, we reported that enema administration of 5-HT4 agonists accelerates recovery from colitis, and increases epithelial proliferation, wound healing and resistance to oxidative stress. We are now interested in testing whether 5-HT4 agonists that specifically target these receptors can accelerate motility and aid in the reversal of colitis.
Modulation of serotonin signaling by probiotics. Serotonin is an important signaling molecule in the brain, in the gastrointestinal tract, and in many other peripheral tissues. We are testing whether serotonin levels can be up- and/or down-regulated by probiotic treatments.
研究兴趣
论文共 225 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Neurogastroenterology and motilityno. 11 (2023): e14673-e14673
Johanna Holman, Lola Holcomb, Louisa Colucci, Dorien Baudewyns, Joe Balkan,Grace Chen,Peter Moses,Gary Mawe,Tao Zhang,Yanyan Li,Suzanne Ishaq
Current Developments in Nutrition (2023): 101527-101527
biorxiv(2023)
MSYSTEMSno. 6 (2023): 101526-101526
引用0浏览0引用
0
0
Physiological Reviewsno. 2 (2023): 1487-1564
引用0浏览0引用
0
0
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Societyno. 10 (2023): e14629-e14629
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn