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个人简介
Dr. Firestein’s research interest has focused on the pathogenesis and treatment of rheumatoid arthritis. He was among the first to map the synovial cytokine profile of RA and demonstrate the dominance of macrophage and fibroblast products. These studies played a pivotal role in the development of the highly effective anti-TNF and other anti-cytokine approaches to RA. Dr. Firestein has also studied the role of aggressive synoviocyte behavior in RA as a mechanism of joint destruction and implicated tumor suppressor genes mutations in the pathogenesis of disease. Over the last decade, his laboratory has worked extensively on signal transduction pathways as potential therapeutic targets. These studies identified key signaling molecules regulating synovial inflammation and paved the way to several effective oral small molecule inhibitors that are currently in late phase clinical development for RA. More recently, Dr. Firestein has focused on epigenetics and discovered a DNA methylation signature specific to RA. In addition, he directed a number of innovative clinical studies for the treatment of rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, scleroderma, and autoinflammatory syndromes with a focus on developing novel biomarker endpoints.
研究兴趣
论文共 517 篇作者统计合作学者相似作者
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Sho Sendo, Camilla R L Machado,David L Boyle, Robert J Benschop,Narayanan B Perumal, Eunice Choi,Wei Wang,Gary S Firestein
Arthritis & rheumatology (Hoboken, N.J.) (2024)
Aileen Y Chang,Sarah R Tritsch,Carlos Andres Herrera Gomez,Liliana Encinales,Andres Cadena Bonfanti,Wendy Rosales,Evelyn Mendoza-Torres, Samuel Simmens,Richard L Amdur, Christopher N Mores, Paige Fierbaugh,Carlos Alberto Perez Hernandez,
PloS oneno. 3 (2024): e0299521-e0299521
Benjamin Van Espen, E Barton Prideaux,Andrew R Wilson, Camilla R L Machado, Sho Sendo, James Parker,Grégory Seumois,Cristiano Sacchetti, Anna C Belongia,Narayanan B Perumal, Pandurangan Vijayanand,Matthew D Linnik,
Arthritis & rheumatology (Hoboken, N.J.) (2024)
bioRxiv : the preprint server for biology (2024)
Ellen M Gravallese,Gary S Firestein, Natalie Koscal, Emily Ling, Dan L Longo, Lori A Messenger, Abigail Schubach
The New England journal of medicineno. 13 (2024): e32-e32
Jun Inamo,Joshua Keegan,Alec Griffith,Tusharkanti Ghosh,Alice Horisberger,Kaitlyn Howard, John Pulford, Ekaterina Murzin,Brandon Hancock,Anna Helena Jonsson,Jennifer Seifert,Marie L Feser,
bioRxiv : the preprint server for biology (2023)
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Journal of clinical and translational scienceno. 1 (2023): e180-e180
Camilla R. L. Machado,Gary S. Firestein
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Circulationno. Suppl_1 (2023)
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