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Gary Martin is an American chemist and expert in the fields of both NMR spectroscopy and medicinal chemistry. He is a distinguished fellow at the Merck Research Laboratories. He is also a photographer specializing in the capture of images of lighthouses, especially under conditions of extreme weather.Career[edit]
Martin holds a B.S. in Pharmacy from the University of Pittsburgh and a Ph.D. degree in Medicinal Chemistry/Pharmaceutical Sciences from the University of Kentucky.[3] He was a Professor of Medicinal Chemistry at the University of Houston from 1975–1989 and the director of the University of Houston NMR Facility between 1984-1989. He moved to the pharmaceutical industry in 1989 and worked at a number of pharmaceutical companies as described below. He has published more than 275 papers, invited reviews, and chapters and is a frequently invited lecturer at national and international NMR meetings. Research interests[edit]
His ongoing research interests have centered on the development of new NMR methods for the characterization of impurities and degradants of pharmaceuticals focusing on the exploration of new NMR probe technologies for the characterization of extremely small samples using heteronuclear 2D-NMR methods. His interests in this area were pivotal in the development of 3 mm and 1.7 mm probe technologies and he was also an early proponent of cryogenic probe capabilities.,[13][14]
He has had a long-standing interest in heteronuclear NMR and 2D long-range heteronuclear shift correlation in particular. He was among the first to exploit natural abundance long-range 1H-15N heteronuclear shift correlation experiments, those early reports leading to hundreds of published reports that are the subject of multiple reviews and chapters.,[15][16] More recently, his research interests have also led to the development of unsymmetrical indirect covariance NMR processing methods that have the potential for significant spectrometer time savings when experimental access to hyphenated 2D NMR. These methods also provide access to 13C-15N Heteronuclear Single Quantum Coherence-Heteronuclear Multiple Bond Coherence (HSQC-HMBC) correlation data that are experimentally inaccessible at natural abundance, and to HSQC-ADEQUATE correlation plots that allow carbon-carbon connectivity networks of molecules to be mapped without having to resort to the highly insensitive 13C-13C INADEQUATE experiment.
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