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Garegin Papoian is the Monroe Martin Professor, with joint appointment in Chemistry and Institute for Physical Science and Technology. His group is striving to understand complex biological phenomena based on fundamental physical and chemical principles. His current research interests include DNA packing in cells of higher organisms and cellular cytoskeleton and motility.
Students and postdocs in the Papoian group use theoretical physical chemistry techniques, including advanced computational methods, to study biological processes at multiple scales, from single protein functional dynamics and chromatin folding and stability to cell-level processes, such as stochastic signal transduction and regulation of cell motility. Group members are exposed to diverse areas of equilibrium and nonequilibrium statistical mechanics, polymer physics, computational protein modeling and bioinformatics. Two on-going projects are briefly outlined below.
The Papoian group develops detailed computational models of the way eukaryotic cells move around and sense their environment. Cell motility plays a key role in human biology and disease, contributing ubiquitously to such important processes as embryonic development, wound repair and cancer metastasis. Physical chemistry behind these complex, far-from-equilibrium mechano-chemical processes are poorly understood. Papoian group’s research aims to elucidate the mechanism and dynamics of the self-assembly of actin-filament networks and bundles, which, in turn, drive cell’s leading edge and allow the cell to project long, finger-like protrusions to probe for attractant and repellant cues in cell’s exterior. They collaborate with biologists to experimentally verify computational model predictions and suggest new classes of experiments. Successful completion of their research would allow for better rational control of biochemical reaction circuits that regulate eukaryotic cell motility.
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Scientific Reportsno. 1 (2023): 1-13
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Scientific reportsno. 1 (2023): 8662
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Open biologyno. 6 (2023): 220359
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Qin Ni,Kaustubh Wagh, Aashli Pathni,Haoran Ni, Vishavdeep Vashisht,Arpita Upadhyaya,Garegin A Papoian
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