基本信息
浏览量:2
职业迁徙
个人简介
Research interests
My research group focuses on elucidating the genetic mechanisms of the interaction of the pathogens with the host using avant-garde technologies. Resistance from pathogens to antibiotics or antiparasitic drugs is a growing concern and affects millions patients worldwide every year. There is an urgent need to find novel treatment to improve the care of people as bacteria or parasites are becoming resistant to all existing antibiotics and antiparasitic agents. Novel & innovative strategies are desperately needed for this problem. In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. My group aim to understand why these people are resistant to pathogens using mouse as a model. Using genomic technologies (DNA and RNA sequencing), advanced mouse genetic technologies (ENU mutagenesis in mice, Collaborative Cross in mice) or transgenesis technologies such as CRISPR/Cas9 mediated genome editing in mice or pathogens, we aim to dissect mechanisms of the host resistance to pathogens (hospital acquired infection as well as malaria) as well as the mechanisms of interaction of the pathogens to the host.
My research group focuses on elucidating the genetic mechanisms of the interaction of the pathogens with the host using avant-garde technologies. Resistance from pathogens to antibiotics or antiparasitic drugs is a growing concern and affects millions patients worldwide every year. There is an urgent need to find novel treatment to improve the care of people as bacteria or parasites are becoming resistant to all existing antibiotics and antiparasitic agents. Novel & innovative strategies are desperately needed for this problem. In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. My group aim to understand why these people are resistant to pathogens using mouse as a model. Using genomic technologies (DNA and RNA sequencing), advanced mouse genetic technologies (ENU mutagenesis in mice, Collaborative Cross in mice) or transgenesis technologies such as CRISPR/Cas9 mediated genome editing in mice or pathogens, we aim to dissect mechanisms of the host resistance to pathogens (hospital acquired infection as well as malaria) as well as the mechanisms of interaction of the pathogens to the host.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
P. Acera Mateos, A.J. Sethi, A. Ravindran,A. Srivastava, M. Kanchi, S. Mahmud,M. Guarnacci, K. Woodward, J. Xu, Z.W.S. Yuen, Y. Zhou, A. Sneddon,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
引用5浏览0引用
5
0
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 434
Yaoyuan Zhang,Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo,Xiangpeng Meng,Nadia J. Kershaw,Pamudika Kiridena,Gaetan Burgio, Simon Gross,Jean Y. Cappello,Qian Shen,Hao Wang,
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Nirmal Bhatt, Connor Anderson, Theresa Nguyen, Gabriel Rodriguez,Gaetan Burgio,Simon Jiang,Aniruddh Deshpande,Malcolm Starkey
引用0浏览0引用
0
0
Grant J. Brown,Pablo F. Cañete,Hao Wang, Arti Medhavy,Josiah Bones,Jonathan A. Roco,Yuke He,Yuting Qin,Jean Cappello,Julia I. Ellyard,Katharine Bassett,Qian Shen,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn