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个人简介
His work is based around heart failure and the molecular mechanisms involved in the regulation of signaling through cardiovascular adrenergic receptors, the study of G-protein coupled receptor function and signaling, and heart failure gene therapy. His recent studies are investigating into the use of novel viral-mediated myocardial gene delivery for use in congestive heart failure, with an aim at developing reproducible surgical means of gene therapy. He is also involved in research to understand novel molecular signaling mechanisms responsible for the beneficial effects of exercise training and beta-blocker therapy in animal model of heart failure and aging. He is studying new molecular mechanism responsible of neurohormonal overdrive observed in heart failure. In particular he reported the first demonstration of a molecular mechanism for sympathetic nervous system hyperactivity in heart failure by identifying adrenal GRK2 activity as a new sympatholytic target. He described a new interaction between β-1 adrenergic receptor and sphingosine 1 phosphate receptor 1 that has a relevant role in HF pathogenesis and progression. Inhibition of this GRK2-dependent interaction is therapeutic in HF. More recently, Giuseppe has demonstrated that blood GRK2 levels can independently predict prognosis in HF patients, providing a new prospective for the clinical utility of GRK2 in HF. Finally, he has provided the first evidence of a direct correlation between increased epicardial adipose tissue thickness and cardiac sympathetic denervation, demonstrating that epicardial adipose tissue is a relevant source of catecholamine.
研究兴趣
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ERJ Open Researchpp.00090-2024, (2024)
JOURNAL OF CLINICAL MEDICINEno. 2 (2024): 585
Journal of the American Medical Directors Associationno. 3 (2024): 465-469
GeroScienceno. 1 (2024): 99-111
Frontiers in Endocrinology (2024)
Giovanni Carbone,Leonardo Bencivenga, Maria Angela Santoro,Natascia De Lucia,Maria Emiliana Palaia, Erica Ercolano,Francesco Scognamiglio,Paul Edison,Nicola Ferrara, Dino Franco Vitale,Giuseppe Rengo,Grazia Daniela Femminella
Frontiers in endocrinology (2024): 1389014-1389014
Stefano Salvioli, Maria Sofia Basile,Leonardo Bencivenga, Sara Carrino,Maria Conte,Sarah Damanti,Rebecca De Lorenzo,Eleonora Fiorenzato,Alessandro Gialluisi,Assunta Ingannato,Angelo Antonini,Nicola Baldini,
Ageing research reviews (2023): 102044-102044
Carlo Rengo,Alessandra Valletta,Daniela Liccardo,Gianrico Spagnuolo,Graziamaria Corbi, F. De Luca, Maria Rosaria Lauria, Alessia Perrotta,Giuseppe Rengo,Nicola Ferrara,Sandro Rengo,Rosa Valletta,
Journal of gerontology and geriatricspp.1-13, (2023)
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