Résultats : The principal contributions of Gérard Jaouen to the development of bioorganometallic chemistry whose potential he first foresaw are : A new type of FT-IR-based bioassay, named CMIA (Carbonyl Metallo ImmunoAssay), the principle of which has now been adopted for IR imaging in Asia (Singapore, Hong Kong) and in Europe The development of an unprecedented multi-immunoassay based on CMIA The synthesis of organometallic suicide substrates for use in studies of the active sites of hormone receptors Access to radiopharmaceuticals with very high affinity for the target receptor The concept of “ferrocifens” with double functionality against hormone-independent breast cancers The area of artificial organometallic enzymes, “OMzymes”, the first alderases The intra cancer cell selective activation of polyphenols into mild quinone methides thanks to an innovating organometallic redox antenna, changing the paradigm for metallodrugs (senescence, apoptosis, bioavailability, unique mechanisms via a kronatropic effect, and first in vivo results on glioma and epithelial ovarian cancers included) The identification of specific redox proteins overexpressed in cancer cells and targeted by ferrocifen cytostatic derivatives in order to trigger senescence for these cells when apoptosis is not operating (so far incurable tumors).This mitochondrial approach inducing a senescence trail can circumvent cancer cells resistant to pro-apoptotic stimuli