基本信息
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职业迁徙
个人简介
Current Research and Scholarly Interests
We are interested in the role of chromatin regulation in development and human cancer. Recent studies have show that over 20% of all human cancers have mutations in the subunits of an ATP-dependent chromatin regulatory complex we discovered several years ago. The genes behave as tumor suppressors and sometimes as oncogenes. We hope to understand the fundamental mechanisms used by these complex to prevent cancer.
These same chromatin remodeling complexes are frequently mutated in a variety of human neurologic diseases, reflecting their roles in the development of the nervous system. It appears that these specialized roles in the nervous system are due to the use of unique neural specific assemblies in the developing human and mouse brain. We hope to understand their fundamental mechanism of action through biochemical and genetic approaches in combination with genome-wide analysis and genome sequencing studies.
Finally, we are developing new ways of making conditional alleles of mammalian genes using synthetic ligands that we hope will bring about a new fusion of biochemical and genetic approaches to understanding and controlling fundamental biologic processes. Recently we have developed an effective way of both assaying and modifying chromatin regulation in living cells.
研究兴趣
论文共 480 篇作者统计合作学者相似作者
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Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
Nature Immunologypp.1-13, (2024)
Noah Gamble, Alexandra Bradu, Jason A Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J Greenleaf,Gerald R Crabtree,
Nature immunology (2024)
Hideo Hagihara,Hirotaka Shoji,Satoko Hattori,Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka,Masafumi Ihara, Mihiro Shibutani,Izuho Hatada,Kei Hori,Mikio Hoshino,Akito Nakao,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
Nature Immunology (2024)
Hideo Hagihara, Hirotaka Shoji,Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka,Masafumi Ihara, Mihiro Shibutani, Izuho Hatada,Kei Hori,Mikio Hoshino,Akito Nakao,
ELIFE (2024)
biorxiv(2023)
Nature Reviews Geneticsno. 5 (2023): 1-22
bioRxiv : the preprint server for biology (2023)
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Roman C Sarott,Sai P Gourisankar, Basel Aydon Karim, Sabin Nettles,Haopeng Yang, Brendan Dwyer, Juste M Simanauskaite,Jason Tse, Hind Abuzaid,Andrey Krokhotin,Tinghu Zhang,Stephen M Hinshaw,
bioRxiv : the preprint server for biology (2023)
NATURE (2023)
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