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The Murphy Group studied cell surface proteinases that modulate both the extracellular matrix and the activities of key cytokines and growth factors and have generated information on their structure function relationships that are key to the understanding of their role in biology and pathology and the design of novel therapeutic approaches to cancer. These enzymes are located on both tumour and interacting stromal cells and are regulated by trafficking which allows specific localisation in events such as cell invasion. The identification of the importance of specific enzyme domains has also generated novel ideas for the production of novel inhibitors.
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论文共 218 篇作者统计合作学者相似作者
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Riccardo E. Nisato, Ghamartaj Hosseini, Christian Sirrenberg,Georgina S. Butler, Thomas Crabbe, Andrew J.P. Docherty, Matthias Wiesner,Gillian Murphy, Christopher M. Overall,Simon L. Goodman,Michael S. Pepper
crossref(2023)
Riccardo E. Nisato, Ghamartaj Hosseini, Christian Sirrenberg,Georgina S. Butler, Thomas Crabbe, Andrew J.P. Docherty, Matthias Wiesner,Gillian Murphy, Christopher M. Overall,Simon L. Goodman,Michael S. Pepper
crossref(2023)
semanticscholar(2019)
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