George M. Carman
教授
Robert Wood Johnson Medical School
Rutgers University;Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers University;Department of Food Science, Rutgers University;School of Arts and Sciences, Rutgers University
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Research in our laboratory utilizes molecular genetics and biochemical approaches to study the regulation of phospholipid metabolism in the yeast Saccharomyces cerevisiae. Phospholipids are essential molecules that contribute to the structural definition of cell membranes, and participate in the regulation of cellular processes as signaling molecules and as reservoirs of lipid messengers. Our laboratory has made significant contributions to the understanding of phospholipid synthesis in yeast through the purification and characterization of several enzymes, and through the isolation and characterization of key genes. The laboratory has played a major role in the discovery that the expression of phospholipid synthesis enzymes is regulated by phospholipid precursors (e.g., inositol, choline, ethanolamine, and serine) and the mineral zinc; and that key enzymes are regulated by membrane (e.g., phospholipids, sphingolipids) - and cytosolic (e.g., inositol, serine, ATP, CTP) -associated components, by covalent modifications via protein kinases and protein phosphatases, and by proteasome-mediated degradation. These forms of enzyme regulation have profound effects on membrane phospholipid composition and cell physiology, and have important implications for understanding the molecular basis for lipid-based diseases (e.g., obesity, lipodystrophy, diabetes, and heart disease).
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Journal of Biological Chemistryno. 1 (2024): 105560-105560
The Journal of biological chemistryno. 1 (2024): 105587-105587
Journal of Biological Chemistryno. 3 (2023): 103801-103801
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S424-S424
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Journal of Biological Chemistryno. 3 (2023): 103807-103807
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S428-S428
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Journal of Biological Chemistryno. 3 (2023): 103810-S429
JOURNAL OF BIOLOGICAL CHEMISTRYno. 7 (2023): 104894-104894
JOURNAL OF BIOLOGICAL CHEMISTRYno. 8 (2023): 105025-105025
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