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个人简介
The main focus of my lab is finding novel gene therapy approaches for intractable neurological diseases, with rapid potential for translation. We start by investigating the pathophysiological mechanisms of disease and then use novel insights to develop and improve therapeutic tools to cure them.
We use cutting-edge technologies such as CRISPR and synthetic promoters to overcome current limitations to gene therapy and develop new approaches for curing currently untreatable genetic diseases such as Dravet Syndrome and Episodic Ataxia-1, and acquired pharmaco-resistant temporal lobe epilepsies.
We use techniques ranging from molecular biology to in vitro and in vivo electrophysiology, in both cell lines and animal models, and iPSC-derived neurons from patients. We collaborate with several groups worldwide to complement our techniques and to accelerate our goal of finding innovative cures for devastating pathologies.
Current and previous positions:
2019-2022: MRC New Investigator at University College of London (UCL), Institute of Neurology. London
2018-2021: Principal Investigator: Epilepsy Research UK fellowship at University College of London (UCL), Institute of Neurology. London
2016-2018: Research Fellow: Horizon 2020- Marie Curie Individual fellowship at University College of London (UCL), Institute of Neurology. London, UK
2014-2016: Research Associate at University College of London (UCL), Institute of Neurology. London, UK
2012-2014: Junior Post-doc at Italian Institute of Technology (IIT), Neuroscience and Brain Technologies Department.
2009-2011: PhD Student at University of Genoa and Italian Institute of Technologies (IIT), Neuroscience and Brain Technologies Department.
Studies:
2012: PhD degree in Experimental Neuroscience at the University of Genova in collaboration with Italian Institute of Technology
2008: MSc in Medical-pharmaceutical Biotechnologies (Neuroscience) at the University of Genova
2006: BSc in Medical Biotechnologies at the University of Milan
We use cutting-edge technologies such as CRISPR and synthetic promoters to overcome current limitations to gene therapy and develop new approaches for curing currently untreatable genetic diseases such as Dravet Syndrome and Episodic Ataxia-1, and acquired pharmaco-resistant temporal lobe epilepsies.
We use techniques ranging from molecular biology to in vitro and in vivo electrophysiology, in both cell lines and animal models, and iPSC-derived neurons from patients. We collaborate with several groups worldwide to complement our techniques and to accelerate our goal of finding innovative cures for devastating pathologies.
Current and previous positions:
2019-2022: MRC New Investigator at University College of London (UCL), Institute of Neurology. London
2018-2021: Principal Investigator: Epilepsy Research UK fellowship at University College of London (UCL), Institute of Neurology. London
2016-2018: Research Fellow: Horizon 2020- Marie Curie Individual fellowship at University College of London (UCL), Institute of Neurology. London, UK
2014-2016: Research Associate at University College of London (UCL), Institute of Neurology. London, UK
2012-2014: Junior Post-doc at Italian Institute of Technology (IIT), Neuroscience and Brain Technologies Department.
2009-2011: PhD Student at University of Genoa and Italian Institute of Technologies (IIT), Neuroscience and Brain Technologies Department.
Studies:
2012: PhD degree in Experimental Neuroscience at the University of Genova in collaboration with Italian Institute of Technology
2008: MSc in Medical-pharmaceutical Biotechnologies (Neuroscience) at the University of Genova
2006: BSc in Medical Biotechnologies at the University of Milan
研究兴趣
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BRAINno. 2 (2024): 542-553
C Bimbard, F Takacs, J M J Fabre, M D Melin,N O'Neill, M Robacha,J S Street,E H Van Beest,A K Churchland,K D Harris,D M Kullmann,G Lignani,
bioRxiv : the preprint server for biology (2023)
EPILEPSY CURRENTSno. 2 (2023): 124-126
EPILEPSY CURRENTSno. 5 (2023): 309-311
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Epilepsy currentsno. 1 (2023): 58-60
Nature Communicationsno. 1 (2022): 1-18
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