基本信息
浏览量:3
职业迁徙
个人简介
Research Interests, Projects, and Approaches
Microorganisms have dominated the history of Earth, playing an intimate role in shaping its chemical and physical properties. Microbes continue their role as agents of biogeochemistry today as they drive a wide range of processes, including the cycling of carbon, oxygen, nitrogen, sulfur, and metals. My research interests are focused on this interplay between the biosphere and the geosphere, examining how microbes drive geochemistry and how geochemistry in turn shapes microbial diversity, metabolism, and evolution. Many biogeochemical cycles are actively driven by genetically encoded molecules that are often carefully regulated to be produced only under certain environmental or physiological conditions. Thus an understanding of biogeochemical cycles that take place on global scales demands knowledge of dynamics that take place on molecular scales. As such, my research relies heavily on molecular-biological approaches that are closely coupled with geochemical approaches to achieve an integrated view of geomicrobiology.
Current and past research projects include:
Genetics, biochemistry, physiology, and genomics of Mn(II)-oxidizing bacteria that catalyze the formation of biogenic Mn oxides. Work in this area has focused on a marine a-proteobacteria and Bacillus spores.
Diversity and function of microbial communities in deep-sea hydrothermal plumes. This project investigates the microbially-mediated formation of Mn oxides in deep-sea hydrothermal vent plumes in Guaymas Basin (Gulf of California). It also addresses questions of how deep-sea microbial communities respond to and transform potential energy sources emanating from deep-sea hydrothermal vents, such as methane, ammonium, sulfur, iron, and manganese.
Microbial community genomics of acid mine drainage (AMD). This project, in Jill Banfield's laboratory (http://seismo.berkeley.edu/~jill/banres.html), investigates how microbes drive the dissolution of pyrite and the formation of acid mine drainage. Community genomics and proteomics are used to understand molecular mechanisms and evolutionary processes in this extremely acidic, chemolithoautotrophic ecosystem. My work has focused on sulfur cycling, assembly of metagenomic DNA sequences, and bioinformatic methods to analyze low-abundance community members.
Approaches and technical interests:
Genomics (metagenomics) and proteomics of microbial communities in natural environments; functional approaches for identifying genes and enzymes.
Bioinformatics.
Biochemistry: protein purification and enzyme function.
Microbial physiology: isolation and physiological studies of microbes in pure culture.
Field(s) of Study
Geomicrobiology
Marine microbiology and oceanography
Molecular mechanisms of biogeochemical processes
Molecular evolution
Genomics, metagenomics, proteomics, and bioinformatics
Microbial metabolic diversity
Astrobiology and life in extreme environments
Microorganisms have dominated the history of Earth, playing an intimate role in shaping its chemical and physical properties. Microbes continue their role as agents of biogeochemistry today as they drive a wide range of processes, including the cycling of carbon, oxygen, nitrogen, sulfur, and metals. My research interests are focused on this interplay between the biosphere and the geosphere, examining how microbes drive geochemistry and how geochemistry in turn shapes microbial diversity, metabolism, and evolution. Many biogeochemical cycles are actively driven by genetically encoded molecules that are often carefully regulated to be produced only under certain environmental or physiological conditions. Thus an understanding of biogeochemical cycles that take place on global scales demands knowledge of dynamics that take place on molecular scales. As such, my research relies heavily on molecular-biological approaches that are closely coupled with geochemical approaches to achieve an integrated view of geomicrobiology.
Current and past research projects include:
Genetics, biochemistry, physiology, and genomics of Mn(II)-oxidizing bacteria that catalyze the formation of biogenic Mn oxides. Work in this area has focused on a marine a-proteobacteria and Bacillus spores.
Diversity and function of microbial communities in deep-sea hydrothermal plumes. This project investigates the microbially-mediated formation of Mn oxides in deep-sea hydrothermal vent plumes in Guaymas Basin (Gulf of California). It also addresses questions of how deep-sea microbial communities respond to and transform potential energy sources emanating from deep-sea hydrothermal vents, such as methane, ammonium, sulfur, iron, and manganese.
Microbial community genomics of acid mine drainage (AMD). This project, in Jill Banfield's laboratory (http://seismo.berkeley.edu/~jill/banres.html), investigates how microbes drive the dissolution of pyrite and the formation of acid mine drainage. Community genomics and proteomics are used to understand molecular mechanisms and evolutionary processes in this extremely acidic, chemolithoautotrophic ecosystem. My work has focused on sulfur cycling, assembly of metagenomic DNA sequences, and bioinformatic methods to analyze low-abundance community members.
Approaches and technical interests:
Genomics (metagenomics) and proteomics of microbial communities in natural environments; functional approaches for identifying genes and enzymes.
Bioinformatics.
Biochemistry: protein purification and enzyme function.
Microbial physiology: isolation and physiological studies of microbes in pure culture.
Field(s) of Study
Geomicrobiology
Marine microbiology and oceanography
Molecular mechanisms of biogeochemical processes
Molecular evolution
Genomics, metagenomics, proteomics, and bioinformatics
Microbial metabolic diversity
Astrobiology and life in extreme environments
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
E. Anders Kiledal,Laura A. Reitz, Esmee Q. Kulper,Jacob Evans, Ruqaiya Siddiqui,Vincent J. Denef,Gregory J. Dick
HARMFUL ALGAE (2024): 102580-102580
Applied and Environmental Microbiologyno. 5 (2023)
引用0浏览0引用
0
0
MLIFEno. 4 (2023): 401-415
Nature Medicineno. 11 (2023): 2805-2813
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Zhichao Zhou,Patricia Q. Tran, Alyssa M. Adams,Kristopher Kieft,John A. Breier, Rupesh K. Sinha, Kottekkatu P. Krishnan,P. John Kurian,Caroline S. Fortunato, Cody S. Sheik,Julie A. Huber,Meng Li,
biorxiv(2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn