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个人简介
Dr. Aguilera’s research sought to establish a basic understanding of the neuroendocrine mechanisms underlying homeostatic regulation during stress with emphasis on the regulation of the components of the hypothalamic pituitary adrenal axis, neurohypophyseal and autonomic systems. Over the years her laboratory made important contributions to the current knowledge on the regulation and the relative roles of corticotropin releasing hormone (CRH) and vasopressin on the HPA axis, and characterization of the properties, signaling-transduction and regulation of the receptors and actions for these peptide hormones. In addition, to determining the role of vasopressin on the stress response, the work identified novel effects of vasopressin as a neuroprotective agent and trophic factor for the pituitary corticotroph. Her most recent work demonstrating that activation of CRH transcription requires the CREB coactivator, Transducer of Regulated CREB activity (TORC), regulated by the protein kinase, salt inducible kinase (SIK), uncovered a missing link in current knowledge of the regulation of CRH transcription. In keeping with the importance of a cyclic AMP responsive element (CRE) in the CRH promoter in the regulation of CRH transcription, Dr. Aguilera and her colleagues demonstrated that HPA axis hyperactivity following early life stress is associated with increased CRH transcription in response to stress, and hypomethylation CRH promoter CRE. In addition, research addressing the mechanisms of pulsatility of glucocorticoid secretion recently demonstrated that each ACTH-induced secretory pulse is associated with induction of steroidogenic proteins transcription.
研究兴趣
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Molecular Neuroendocrinologypp.375-403, (2016)
Yoskaly Lazo-Fernandez,Greti Aguilera,Truyen D. Pham, Annie Y. Park,William H. Beierwaltes,Roy L. Sutliff,Jill W. Verlander,Karel Pacak,Adeboye O. Osunkoya, Carla L. Ellis,Young Hee Kim,Gregory L. Shipley,
Interdisciplinary Information Sciencesno. 3 (2015): 273-282
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