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One of the main questions addressed in Dr. Furlong's laboratory is the genetic variability of insecticide metabolism and sensitivity in humans. His research group has cloned and sequenced the cDNA's from humans, rabbits, and mice that encode paraoxonase (PON1) an HDL-associated enzyme that inactivates the toxic metabolites of several toxic organophosphate pesticides and nerve agents. The molecular basis of the genetic polymorphism in humans that specifies high or low metabolism has been identified. Dr. Furlong has worked closely with Dr. Lucio Costa in developing a mouse model that has provided valuable information on the role of PON1 in protecting against insecticide exposure.
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Molecular biology and evolutionno. 5 (2023)
biorxiv(2022)
Current protocolsno. 1 (2021)
JOURNAL OF HEALTH AND POLLUTIONno. 24 (2019): S26-S31
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