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The Slack laboratory is at the forefront of the small RNA revolution. They co-discovered the first human microRNA, let-7 and showed that it is a tumor suppressor that controls key cancer genes, such as RAS, MYC and LIN28. They are developing let-7 and a second microRNA, miR-34 as novel cancer therapeutics with miR-34 already in Phase I clinical trials. They also proved that microRNAs act as key oncogenes and developed strategies to target these oncomiRs for cancer therapy. Their research also extends to discovery of additional novel small RNAs in development, cancer, aging and diabetes as well as identifying novel SNPs in the non-coding portions of the genome with an eye to identifying the next generation of actionable targets in cancer.
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论文共 370 篇作者统计合作学者相似作者
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Urmila Jagtap, Anan Quan, Yuho Ono,Jonathan Lee, Kylie A. Shen,Sergei Manakov,Gyongyi Szabo,Imad Nasser,Frank J. Slack
Cancer Researchno. 6_Supplement (2024): 5689-5689
Beatriz C. Tonin, Ana L. Ayub, André H. Lengert, Sang W. Han, Eduardo M. Reis,Frank J. Slack, Miriam G. Jasiulionis
Cancer Researchno. 6_Supplement (2024): 5684-5684
Elena Ratner,Lingeng Lu,Marta Boeke, Rachel Barnett,Sunitha Nallur, Lena J. Chin,Cory Pelletier,Rachel Blitzblau,Renata Tassi,Trupti Paranjape,Pei Hui,Andrew K. Godwin,
crossref(2023)
Cancer Researchno. 7_Supplement (2023): 3755-3755
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BRIEFINGS IN BIOINFORMATICSno. 6 (2023)
Cancer researchno. 6 (2023): 809-813
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI (2023)
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