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Prof. Dr. Frank Buchholz is full Professor for medical systems biology and head of translational research at the university cancer center of the TU Dresden since 2010. As a PhD student till 1997 at the European Molecular Biology Laboratory (EMBL) in Heidelberg, he performed seminal work to implement and improve site-specific recombinases for genome engineering. During his postdoctoral time at the University of California San Francisco (UCSF), he showed for the first time that these enzymes can induce a predefined chromosomal translocation in vivo and he invented substrate-linked directed evolution to breed recombinases with novel specificities. He perfectionated this approach as an independent group leader at the MPI-CBG from 2002 till 2010 to develop the Tre recombinase, an enzyme that can eradicate HIV from infected cells. The approach is now developed into a designer-recombinase platform technology and is supported by a number of research grants. Prof. Dr. Frank Buchholz is also widely known for his development of the esiRNA technology and its implementation as an efficient and specific RNAi screening tool. Employing this tool, he has discovered many new genes relevant for stem cell biology and human diseases. His group has recently extended functional profiling via RNAi and CRISPR/Cas9 technology to primary cells, with the goal to apply this technology to personalized medicine.
研究兴趣
论文共 244 篇作者统计合作学者相似作者
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Life science allianceno. 4 (2024)
LIFE SCIENCE ALLIANCEno. 4 (2024)
Niklas Beschorner, Paul Künzle, Maike Voges,Ilona Hauber,Daniela Indenbirken, Jacqueline Nakel, Sanamjeet Virdi,Peter Bradtke,Niels Christian Lory,Michael Rothe,Maciej Paszkowski-Rogacz,Frank Buchholz,
PloS oneno. 3 (2024): e0298542-e0298542
Achim Temme,Alexander Hagstotz,Isabell Schau,Michael Seifert,Duran Sürün, Stefan Zimmermann,Frank Buchholz, Luise Rupp,Rebekka Wehner,Marc Schmitz,Gabriele Schackert,Ilker Y. Eyüpoglu
Cancer Researchno. 7_Supplement (2024)
Liliya Mukhametzyanova,Lukas Theo Schmitt, Julia Torres-Rivera, Teresa Rojo-Romanos,Felix Lansing, Maciej Paszkowski-Rogacz, Heike Hollak,Melanie Brux,Martina Augsburg,Paul Martin Schneider,Frank Buchholz
Nature Biotechnologypp.1-11, (2024)
Cell Reportsno. 10 (2023): 113177-113177
Shady Sayed, Olga A. Sidorova,Alexander Hennig,Martina Augsburg, Catherine P. Cortés Vesga, Moustafa Abohawya, Lukas T. Schmitt, Duran Sürün,Daniel E. Stange,Jovan Mircetic,Frank Buchholz
crossref(2023)
ANNALS OF HEMATOLOGYno. SUPPL 1 (2023): S21-S21
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