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个人简介
We conduct both basic and clinical research programs, focused primarily on development of pathogenesis-driven molecular diagnostics and therapeutics for rare lung diseases. We are an integral part of the Translational Pulmonary Science Center, which is a collaborative project between pulmonary groups at UC and CCHMC, the Rare Lung Diseases Consortium (PIs Trapnell and McCormack), an NIH and NCATs supported platform for conducting studies in rare lung disease.
In our basic research, all projects have a human clinic trial on the horizon, at least conceptually. The laboratory has used mouse models of pulmonary Langerhans cell histiocytosis, Hermansky Pudlak syndrome, lymphangioleiomyomatosis, and pulmonary alveolar microlithiasis in preclinical studies to determine mechanisms of alveolar homeostasis in health and disease. We are also interested in the role of pulmonary airway cells, collectins and lung epithelial cells in innate immune defense against inhaled bacteria, mycobacteria, fungi and viruses, especially (and most recently) influenza.
Our clinical research is focused on investigator-initiated, multicenter, international randomized trials for lymphangioleiomyomatosis, one of which recently led to discovery of an effective treatment and to FDA approval. We are optimistic that our laboratory findings will support the design and execution of trials of phosphate restriction for pulmonary alveolar microlithiasis, BRAF inhibitors for pulmonary Langerhans cell histiocytosis, KGF treatment for pulmonary non tuberculous mycobacterial disease, and mTOR inhibitor prophylaxis and therapy for influenza.
研究兴趣
论文共 364 篇作者统计合作学者相似作者
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Erin Gibbons,Manisha Taya,Huixing Wu, Samia H Lopa,Joel Moss, Elizabeth P Henske,Francis X Mccormack, Stephen R Hammes
Endocrine-related cancer (2024)
Springer eBookspp.177-192, (2023)
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Journal of the Endocrine Societyno. Supplement_1 (2023)
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European Respiratory Reviewno. 169 (2023): 230100-230100
Springer eBookspp.251-274, (2023)
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Clinical trials (London, England)no. 3 (2023): 17407745231158906-234
Santhoshi V Akkenepally,Dan J K Yombo, Sanjana Yerubandi,Geereddy Bhanuprakash Reddy,Deepak A Deshpande,Francis X McCormack,Satish K Madala
Nature communicationsno. 1 (2023): 8207-8207
Katie Noonan, Ronan Hearne,Brian Gaffney,Brian Sheehy,Niall Mcveigh, Yasuhito Sekimoto,Ali Ataya,Nishant Gupta,Francis Mccormack,Raphael Borie,Francesco Bonella,David Murphy,
Imaging (2023)
Springer eBookspp.369-387, (2023)
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