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个人简介
Our lab is interested in how cell death impacts innate inflammation and immune responses. We have a long-standing interest in the biology and signaling mechanism of tumor necrosis factor (TNF), a key cytokine that regulates many inflammatory diseases (e.g. rheumatoid arthritis, inflammatory bowel diseases etc), pathogen infections, and cancer. Several key discoveries made by the PI during his graduate school and postdoctoral training include identification of one of the first cell cycle inhibitors, INK4d-p19 (Mol Cell Biol. 1995, cited over 300 times), and the discovery of the "pre-ligand assembly domain (PLAD)" that mediates TNF receptors signal transduction (Science 2000, cited over 800 times).
研究兴趣
论文共 129 篇作者统计合作学者相似作者
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Anhua Lei, Hua Yu, Shan Lu,Hengxing Lu, Xizhong Ding,Tianyu Tan,Hailing Zhang,Mengmeng Zhu, Lin Tian,Xudong Wang,Siyu Su, Dixuan Xue,
NATURE IMMUNOLOGY (2023)
Cell death and differentiationno. 5 (2023): 1097-1154
Gastrointestinal endoscopyno. 3 (2022): 530-542.e1
European journal of nutritionno. 8 (2021): 4151-4174
Kenta Moriwaki, Christa Park,Kazuha Koyama,Sakthi Balaji, Kohei Kita, Ryoko Yagi,Sachiko Komazawa-Sakon,Manami Semba,Tatsuya Asuka,Hiroyasu Nakano,Yoshihiro Kamada,Eiji Miyoshi,
Zhijun Liu, Himani Nailwal, Jonah Rector,Masmudur M Rahman,Richard Sam,Grant McFadden,Francis Ka-Ming Chan
Immunityno. 2 (2021): 247-258.e7
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