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职业迁徙
个人简介
He is an expert in the molecular and cellular pathways that dictate assembly of viral surface glycoproteins on retroviral nucleocapsids, a process known as “pseudotyping”. His pioneering studies have led to the design of novel, shealthy human gene therapy vectors and to the development of new tools, allowing basic cell entry studies of pathogenic enveloped viruses, such as, e.g., HCV, which could not be grown in tissue culture in 2003. He thus reported the first HCV entry assay, so-called HCVpp (Bartosch et al. J. Exp. Med. 2003). This landmark discovery stimulated numerous studies from his own and many other groups towards in depth analysis of cell entry routes, identification of HCV receptors, mechanisms of neutralization and/or cell entry inhibition and humoral responses in patient cohorts. His team is composed of leading scientists in virology, viral engineering, vectorology, immunology, hematology and stem cell engineering, which provides tremendous expertise for biomedical applications. His work is supported by the European Union (ERC AdG HEPCENT).
研究兴趣
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