I am a clinical academic with a research and clinical focus on young onset and inherited dementias.
I am Professor of Clinical Neurology at UCL’s Queen Square Institute of Neurology and Director of the Dementia Research Centre and am also a consultant neurologist at the National Hospital for Neurology and Neurosurgery where I run a multidisciplinary cognitive clinic.
An active interest is how to support patients and families with these devastating disorders and helped to set up the first support groups that now are part of Rare Dementia Support
My research focus has been on improving diagnosis and using imaging and biomarkers to accelerate the search for effective therapies for neurodegenerative dementias. My interests include the early detection, differential diagnosis and monitoring of progression in cognitive disorders and neurodegenerative dementias in particular. Within this broad grouping my research expertise has been in the use of MRI to improve diagnosis and to measure progression in Alzheimer's disease and related disorders. I have been involved in the use of automated measures of cerebral atrophy derived from serial MRI to assess treatment efficacy and disease-modifying potential of novel therapies. I also have a particular interest in the familial dementias and the use of biomarkers and clinical and cognitive measures to assess the earliest manifestations of autosomal dominant dementias, both Alzheimer's disease and frontotemporal lobar degenerations.