Felice C. Lightstone - Department of Chemistry, University of California

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Papers共 199 篇Author StatisticsCo-AuthorSimilar Experts

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Blocking C-terminal Processing of KRAS4b Via a Direct Covalent Attack on the CaaX-box Cysteine

Anna E Maciag, Yue Yang,Alok K Sharma, David M Turner,Caroline J DeHart, Hazem Abdelkarim,Lixin Fan, Brian P Smith, Vandana Kumari, Marcin Dyba,Megan Rigby, Jean A Castillo Badillo, Lauren Adams,Luca Fornelli, Stephen Fox, Alla Brafman,Thomas Turbyville,William Gillette, Simon Messing, Constance Agamasu, Andrew L Wolfe,Stephan Gysin,Albert H Chan,Dhirendra K Simanshu,Dominic Esposito, Oleg Chertov,Andrew G Stephen,Michelle Arkin,Adam Renslo, Neil L Kelleher,Vadim Gaponenko,Felice C Lightstone,Dwight V Nissley,Frank McCormick

Proceedings of the National Academy of Sciences of the United States of Americano. 19 (2025): e2410766122-e2410766122

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Discovery of BBO-8520, a First-in-class Direct and Covalent Dual Inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C

Anna E Maciag, James P Stice, Bin Wang,Alok K Sharma,Albert H Chan, Ken Lin, Devansh Singh,Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P Smith, Jin Hyun Ju, Stevan Jeknic,Dana Rabara, Zuhui Zhang,Erik K Larsen,Dominic Esposito,John-Paul Denson,Michela Ranieri,Mary Meynardie,Sadaf Mehdizadeh, Patrick A Alexander,Maria Abreu Blanco, David M Turner,Rui Xu,Felice C Lightstone,Kwok-Kin Wong,Andrew G Stephen,Keshi Wang,Dhirendra K Simanshu, Kerstin W Sinkevicius,Dwight V Nissley,Eli Wallace,Frank McCormick,Pedro J Beltran

Cancer discoveryno. 3 (2025): 578-594

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Enhanced Exploration of Protein Conformational Space Through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows

Fikret Aydin, Konstantia Georgouli,Loïc Pottier,Tomas Oppelstrup,Timothy S Carpenter, Jeremy O B Tempkin, Peer-Timo Bremer,Dwight V Nissley, Frederick H Streitz,Felice C Lightstone,Helgi I Ingólfsson

The journal of physical chemistry Bno. 20 (2025): 4895-4903

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BBO-10203 Inhibits Tumor Growth Without Inducing Hyperglycemia by Blocking RAS-PI3Kα Interaction

Dhirendra K Simanshu, Rui Xu, James P Stice, Daniel J Czyzyk, Siyu Feng,John-Paul Denson, Erin Riegler, Yue Yang,Cathy Zhang, Sofia Donovan, Brian P Smith, Maria Abreu-Blanco, Ming Chen, Cindy Feng, Lijuan Fu,Dana Rabara, Lucy C Young, Marcin Dyba, Wupeng Yan, Ken Lin, Samar Ghorbanpoorvalukolaie, Erik K Larsen, Wafa Malik, Allison Champagne, Katie Parker, Jin Hyun Ju, Stevan Jeknic,Dominic Esposito, David M Turner,Felice C Lightstone, Bin Wang, Paul M Wehn, Keshi Wang,Andrew G Stephen, Anna E Maciag,Aaron N Hata, Kerstin W Sinkevicius,Dwight V Nissley,Eli M Wallace,Frank McCormick,Pedro J Beltran

Science (New York, NY)pp.eadq2004-eadq2004, (2025)

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9 Oral: BBO-10203, an Orally Bioavailable Small Molecule That Disrupts the RAS-PI3Kα Interaction Leading to Pakt and Tumor Growth Inhibition in Models of Breast, Lung and Colorectal Cancer

D. Simanshu, R. Xu, J. Stice, D. Czyzyk, S. Feng, Y. Yang, J.P. Denson, E. Riegler, C. Zhang, L. Fu, K. Lin,F.C. Lightstone, K. Wang, A.G. Stephen, A.E. Maciag, K. Sinkevicius, D.V. Nissley, E.M. Wallace,F. McCormick, P. Beltran

European Journal of Cancer (2024): 114538

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BBO-8520, a First-in-class, Direct Inhibitor of KRASG12C (ON), Locks GTP-bound KRASG12C in the State 1 Conformation Resulting in Rapid and Complete Blockade of Effector Binding

Anna E. Maciag, James Stice, Bin Wang,Alok Sharma,Albert Chan, Ken Lin, Devansh Singh,Marcin Dyba,Yue Yang, Saman Setoodeh, Brian P. Smith,Dana Rabara, Zuhui Zhang,Erik K. Larsen, Dom Esposito,John Paul Denson,Michela Ranieri,Mary Meynardie,Sadaf Mehdizadeh,Patrick Alexander,Maria Abreu Blanco,David Turner,Rui Xu,Felice C. Lightstone,Kwok Kin Wong,Dhirendra Simanshu,Keshi Wang,Andrew G. Stephen,Kerstin Sinkevicius,Dwight V. Nissley,Eli Wallace,Frank McCormick,Pedro J. Beltran

CANCER RESEARCH（2024）

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Targeting Ras-, Rho-, and Rab-family GTPases Via a Conserved Cryptic Pocket

Johannes Morstein,Victoria Bowcut, Micah Fernando,Yue Yang, Lawrence Zhu,Meredith L. Jenkins, John T. Evans,Keelan Z. Guiley,D. Matthew Peacock, Sophie Krahnke, Zhi Lin, Katrine A. Taran,Benjamin J. Huang,Andrew G. Stephen,John E. Burke,Felice C. Lightstone,Kevan M. Shokat

CELL（2024）

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Abstract ND07: BBO-8520, a First-in-class, Direct Inhibitor of KRASG12C (ON), Locks GTP-bound KRASG12C in the State 1 Conformation Resulting in Rapid and Complete Blockade of Effector Binding

Cancer Researchno. 7_Supplement (2024)

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Revealing the Mechanism of Action of a First-in-class Covalent Inhibitor of KRASG12C (ON) and Other Functional Properties of Oncogenic KRAS by 31P NMR

Alok K. Sharma, Jun Pei,Yue Yang,Marcin Dyba,Brian Smith,Dana Rabara,Erik K. Larsen,Felice C. Lightstone,Dominic Esposito,Andrew G. Stephen, Bin Wang,Pedro J. Beltran,Eli Wallace,Dwight V. Nissley,Frank McCormick,Anna E. Maciag

The Journal of biological chemistryno. 2 (2024): 105650-105650

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