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个人简介
My expertise in tumor angiogenesis and in understanding the cellular and molecular circuits occurring between cancer and stroma cells have been developed over three decades. I have led national and international projects on vascular development, on tumor angiogenesis, fibrosis and the microenvironment. In my own research I have concentrated on the molecular and cellular mechanisms involved in the role of vasculature in tumor progression and metastatic spreading, by focusing on how oncogenic hits impact on the angiogenic mechanisms characterizing singular tumor subtypes and contributing to the onset of acquired resistance to anti-angiogenic regimens.My major interest is in driving the field of the microenvironment in tumor biology forward technically and conceptually. In particular, I’m absolutely convinced that significant progresses in cancer fight, including the route of therapeutic personalized approaches, have to consider cancer as a tissue characterized by cells generally carrying somatic mutations and stroma cells, which differently interact with cancer cells and dynamically influence their behaviour in the host.
研究兴趣
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