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My current research focuses on understanding how eukaryotic cells adapt and survive in hostile environments, particularly those that are polluted with toxic heavy metals. In the laboratory I exposed different species of protists to different concentrations of arsenic (AS III) for different time periods, and then I generate and compare transcriptomic data from treated as well as the control species. This approach allows me to characterize the changes in gene expressions in response to different arsenic concentrations at different time periods; to identify genes that play roles in AS III metabolism, transportation and detoxification as well as to monitor the impact of arsenic concentration on growth rate.
I am also interested to expand my knowledge in areas of marine protist genetics and evolutions, and currently I am working on developing a stable transfection protocol for Bodo saltans, a free living close relative to Trypanosomes. Certain species of marine protozoa are seemingly ubiquitous in the ocean, yet we know little about them due to the lack of genetically tractable model representatives. Genetic manipulation of marine protist will allow us to systematically decipher the gene–gene and gene–environment interactions, and to understand processes underlying the roles of certain protists in biogeochemical cycling and the evolution and ecology of the microbial Eukarya. I am working on this project at Prof. Peter Girguis lab (Harvard) and in collaboration with Dr. Edgcomb (WHOI).
I am also interested to expand my knowledge in areas of marine protist genetics and evolutions, and currently I am working on developing a stable transfection protocol for Bodo saltans, a free living close relative to Trypanosomes. Certain species of marine protozoa are seemingly ubiquitous in the ocean, yet we know little about them due to the lack of genetically tractable model representatives. Genetic manipulation of marine protist will allow us to systematically decipher the gene–gene and gene–environment interactions, and to understand processes underlying the roles of certain protists in biogeochemical cycling and the evolution and ecology of the microbial Eukarya. I am working on this project at Prof. Peter Girguis lab (Harvard) and in collaboration with Dr. Edgcomb (WHOI).
研究兴趣
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Joan M. Bernhard, Luke A. Fisher, Quinne Murphy, Leena Sen, Heidi D. Yeh,Artemis Louyakis,Fatma Gomaa, Megan Reilly,Paola G. Batta-Lona,Ann Bucklin,Veronique Le Roux,Pieter T. Visscher
Frontiers in Microbiology (2023): 1210781-1210781
crossref(2022)
biorxiv(2022)
crossref(2022)
protocols.io (2021)
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