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Fiona Watt's major research interests are in how the differentiated state of adult tissues is maintained and how this information can be harnessed in regenerative medicine and cancer. She studies the mechanisms that control mammalian epidermal stem cell renewal and differentiation, and how these processes are deregulated in cancer, wound healing and inflammatory skin disorders. She has pioneered the concepts that stem cells in all epidermal locations have multi-lineage differentiation potential and that stem cell fate depends on the strength and duration of a given signal. A current focus is to understand what controls the fate of human epidermal stem cells at the single cell level, applying new technologies with remarkable results. Using mouse models she has shown that fibroblasts are not a homogeneous population, but arise from different lineages during development and have different functions in adult skin She is now applying her findings to human skin fibroblasts, with a view to achieving improved skin repair in patients. Other projects explore genetic-microenvironment interactions in human iPS cells and squamous cell carcinomas.
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Clarisse Ganier,Pavel Mazin, Gabriel Herrera-Oropeza,Xinyi Du-Harpur, Matthew Blakeley, Jeyrroy Gabriel,Alexander Predeus, Batuhan Cakir,Martin Prete,Nasrat Harun,Jean-Francois Darrigrand, Alexander Haiser,
Clarisse Ganier,Pavel Mazin, Gabriel Herrera-Oropeza,Xinyi Du-Harpur, Matthew Blakeley, Jeyrroy Gabriel,Alexander V Predeus,Batuhan Cakir,Martin Prete,Nasrat Harun,Jean-Francois Darrigrand, Alexander Haiser,
bioRxiv (Cold Spring Harbor Laboratory)no. 2 (2024): e2313326120-e2313326120
Stem cell reportsno. 11 (2023): 2047-2055
crossref(2023)
The Journal of pathologyno. 1 (2023): 43-54
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Frontiers in cell and developmental biology (2023): 1163825
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