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Professor Stephenson’s molecular neuroscience research group aims to elucidate fundamental mechanisms which contribute to the molecular organization of synapses. She studies mechanisms of mitochondrial transport following her discovery of the TRAK family of kinesin adaptor proteins, key mediators of mitochonbdrial trafficking. Also, her group study neurotransmitter receptors and their associated scaffolding proteins aspiring to understand how protein-protein interactions determine that neurones ensure that appropriate numbers of a particular neurotransmitter receptor subtype with unique pharmacological and biophysical properties are trafficked and targeted to a defined subcellular localization to ensure fidelity of brain function. Both inhibitory and excitatory synapses are studied focusing on GABAA receptors and the NMDA subclass of excitatory L-glutamate receptors respectively. Both receptors are complex, heteromeric, allosterically modulated integral membrane proteins that are implicated in neurological disease: NMDA receptor dysfunction in stroke, neuropathic pain, epilepsy, Alzheimer’s Disease, and schizophrenia whereas GABAA receptor dysfunction is associated with epilepsy, anxiety and panic disorders.
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ACS MEDICINAL CHEMISTRY LETTERSno. 4 (2023): 442-449
Journal of Biological Chemistryno. 12 (2022): 102590-102590
Brain and neuroscience advances (2019): 2398212819858249-2398212819858249
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