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Other fields of interest to Professor Shakhnovich include investigation of microdomain structure in random polymer melts and diffusion-controlled processes in living cells. Current projects include: 1) Development of a new approach to and algorithm for the prediction of stable conformations of a protein, based on a combination of statistical mechanical methods such as mean-field theory, exhaustive enumeration of all conformations within a given fold, and Monte-Carlo dynamical simulation. 2) Development of the quantitative theory of protein stability, which takes into account the majority of interactions in protein molecules. 3) Monte-Carlo simulations of folding of polypeptides in which conformations are exhaustively enumerated. These simulations make it possible to address the "Levinthal paradox" and develop a theory of kinetics of protein folding. Within this project also is an evolutionary question of the way in which sequences which are able to fold evolved. 4) Theory of microdomain structure in random copolymers and analysis of unusual phases in such systems.
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论文共 527 篇作者统计合作学者相似作者
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Ibrahim Sabbarini,Dvir Reif, Kibum Park, Alex McQuown,Anjali Nelliat, Charlotte Trejtnar,Volker Dotsch,Eugene Shakhnovich,Andrew Murray,Vlad Denic
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Sanchari Bhattacharyya,Srivastav Ranganathan,Sourav Chowdhury, BHARAT V ADKAR, Mark Khrapko,Eugene Shakhnovich
biorxiv(2024)
Aniruddha Chattaraj,Eugene I Shakhnovich
biorxiv(2024)
CURRENT OPINION IN SYSTEMS BIOLOGY (2024): 100485
DIGITAL DISCOVERYno. 5 (2023): 1452-1460
C Brandon Ogbunugafor,Rafael F Guerrero, Miles D Miller-Dickson,Eugene I Shakhnovich,Matthew D Shoulders
Physical review. Eno. 5-1 (2023): 054408-054408
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