Etty Benveniste
教授
Center for Women's Reproductive Health
Heersink School of Medicine, The University of Alabama at Birmingham;Comprehensive Cancer Center, Heersink School of Medicine, The University of Alabama at Birmingham;Comprehensive Neuroscience Center, Heersink School of Medicine, The University of Alabama at Birmingham;Ctr for Clinical & Translational Sci, Heersink School of Medicine, The University of Alabama at Birmingham;Immunology Institute, Heersink School of Medicine, The University of Alabama at Birmingham
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个人简介
Dr. Benveniste's research is directed toward understanding how the immune system and central nervous system (CNS) communicate with each other. Specifically, her laboratory is studying the function of shared cytokines/chemokines between cells of the immune and nervous systems. Astrocytes and microglia, the major glial cells of the CNS, have been shown to act as antigen-presenting cells in the CNS. Dr. Benveniste’s group is examining the mechanisms by which cytokines modulate class II major histocompatibility complex (MHC) and CD40 proteins on these cells, with a particular emphasis on delineating the transcriptional machinery that drives expression of these genes. The ability of astrocytes and microglia to secrete several immunoregulatory molecules (tumor necrosis factor, interleukin-6, macrophage chemotactic protein-1, interleukin-8) is also being studied, with an emphasis on the biological stimuli that induce these cytokines/chemokines, intracellular signaling events involved in the response, and the molecular mechanisms of gene regulation. These projects will provide a better understanding of how bidirectional communication occurs between the immune and nervous systems, and how these interactions affect the functionality of glial cells. These studies are also relevant to understanding the pathogenesis of several neurologic diseases such as multiple sclerosis, an autoimmune disease of the CNS, and HIV-1 associated dementia (HAD). Dr. Benveniste has also initiated studies to examine the role of MMPs and IL-8 in astroglioma migration and invasion, and how interferons inhibit these responses at the transcriptional level. In this line of research, her laboratory is examining how interferons inhibit MMP-9 and IL-8 gene expression by utilizing chromatin immunoprecipitation (ChIP) assays to examine the MMP-9 and IL-8 promoters in vivo. Recent studies in the laboratory are focused on the aberrant activation of two signal transduction pathways in astrogliomas; the JAK-STAT pathway and the NF-kB pathway. It is thought that the dysregulation of these signal transduction pathways contributes to the invasiveness of brain tumors, as well as angiogenic properties. As such, the group is exploring the therapeutic potential of inhibitors of the JAK-STAT and NF-kB pathways to treat brain tumor patients.
研究兴趣
论文共 300 篇作者统计合作学者相似作者
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Movement Disordersno. 5 (2023): 743-754
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Frontiers in immunology (2023): 1163987
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Kasey R Skinner,Tomoyuki Koga, Shunichiro Miki,Robert F Gruener,Florina-Nicoleta Grigore,Emma H Torii,Davis M Seelig,Yuta Suzuki,Daisuke Kawauchi,Benjamin Lin,Denise M Malicki,Clark C Chen,
bioRxiv : the preprint server for biology (2023)
Holly Bachus, Erin McLaughlin,Crystal Lewis,Amber M. Papillion,Etty N. Benveniste, Dave Durell Hill,Alexander F. Rosenberg,André Ballesteros-Tato,Beatriz León
biorxiv(2023)
Hongwei Qin,Lianna Zhou, Faris T. Haque, Cynthia Martin-Jimenez,Amy Trang,Etty N. Benveniste,Qin Wang
JOURNAL OF NEUROCHEMISTRY (2023)
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Cayla Hurst,Toni R Leeth,Etty N Benveniste,Robert P Kimberly, Craig Hoesley,LaKisha Mack,Mona N Fouad,David A Rogers,Selwyn M Vickers,Anupam Agarwal
Journal of Immunologyno. 1 (2023): 166.02-166.02
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Talene A. Yacoubian,Yu-Hua Dean Fang, Adam Gerstenecker,Amy Amara,Natividad Stover, Lauren Ruffrage, Christopher Collette,Richard Kennedy,Yue Zhang,Huixian Hong,Hongwei Qin,Jonathan McConathy,
crossref(2022)
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