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Dr. Appella was among the first researchers to identify the tumor suppressor protein p53, and he has studied its roles in the cell and regulation by post-translational modification. He and his colleagues further identified a critical phosphatase that is upregulated by p53 following DNA damage. This phosphatase, Wip1 (PPM1D), is amplified or overexpressed in several human tumors. Dr. Appella’s research currently is focused on exploring the roles of Wip1 in cells and its contribution to tumorigenesis. They additionally are exploring how Wip1 is regulated. Finally, Dr. Appella’s laboratory is working to develop specific inhibitors of Wip1 that could be advanced to the clinic
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Nature Microbiologyno. 5 (2023): 905-918
Junya Wada, Udumbara Rathnayake,Lisa Jenkins,Moosa Mohammadi,Ettore Appella,Paul Randazzo,Lawrence Samelson
Journal of Biological Chemistryno. 3 (2023): 104316-S718
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Kensuke Kumamoto, Elisa A. Spillare,Kaori Fujita,Izumi Horikawa,Taro Yamashita,Ettore Appella,Makoto Nagashima,Seiichi Takenoshita,Jun Yokota,Curtis C. Harris
crossref(2023)
Kensuke Kumamoto, Elisa A. Spillare, Kaori Fujita,Izumi Horikawa,Taro Yamashita,Ettore Appella,Makoto Nagashima,Seiichi Takenoshita,Jun Yokota,Curtis C. Harris
crossref(2023)
Junya Wada, Udumbara Rathnayake,Lisa M Jenkins,Avinash Singh,Moosa Mohammadi,Ettore Appella,Paul A Randazzo,Lawrence E Samelson
The Journal of biological chemistryno. 3 (2022): 101680
Burhan Uyanik,Anastasia R. Goloudina, Aamir Akbarali,Bogdan B. Grigorash,Alexey V. Petukhov,Sunil Singhal,Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette,Tarik Hadi,Ekaterina V. Baidyuk,Hiroyasu Sakai,
NATURE COMMUNICATIONSno. 1 (2021): 3622-15
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