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The major focus of the Cellular Immunology Section over the past 25 years has been furthering our understanding of the function of T regulatory cells (Tregs) that express the transcription factor Foxp3. Our group was one of the first in the world to realize the importance of Treg and we performed many of the initial studies that described their phenotype and function. The study of Tregs is now one of the most active areas of research in basic and clinical immunology and the therapeutic use of Treg is now in the clinic. It was originally assumed that Treg were a dedicated lineage of cells that developed only from thymic precursors, but more recent studies have clearly documented that Foxp3+ T cells also develop from conventional T cells (Tconv) in extra-thymic peripheral sites in vivo, and these are termed peripherally induced Tregs (pTregs). Treg can also be generated in culture in the presence of transforming growth factor-b1 (TGF-b1) and are termed induced Tregs (iTreg). The relative importance of tTreg and pTreg is unknown. Although most of our studies deal with Tregs in mouse models, over the past 15 years we have also carried out studies on human Tregs (hTregs) derived from normal donors. Our ongoing studies are described below and have been divided up into five major projects with significant overlap between the projects. We also intentionally validate new and novel findings that we learn in one species with similar studies in another species, as there appears to be conservation of many aspects of Treg function across the species.
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论文共 285 篇作者统计合作学者相似作者
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Munir Akkaya,Jafar Al Souz, Daniel Williams, Rahul Kamdar,Olena Kamenyeva,Juraj Kabat,Ethan Shevach,Billur Akkaya
ELIFE (2024)
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Journal of Immunologyno. 1 (2023): 64.10-64.10
JOURNAL OF IMMUNOLOGYno. 9 (2023): 1359-1366
JOURNAL OF IMMUNOLOGYno. 1 (2023): 169.15-169.15
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JOURNAL OF IMMUNOLOGYno. 1 (2023): 248.03-248.03
Journal of Immunologyno. 1 (2023): 169.14-169.14
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Journal of immunology (Baltimore, Md. : 1950)no. 9 (2023): 1359-1366
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Soha M. Kazmi,Surajit Sinha,Kannan Natarajan, Suveena Sharma, Yong-Hee Kim,Lisa Boyd,Jonathan Hernandez,David H. Margulies,Ethan M. Shevach,Abir K. Panda
Journal of Immunologyno. 1 (2023): 245.08-245.08
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