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个人简介
My training as a physician scientist motivates me to seek new treatments for chronic lung diseases. I have spent more than 15 years pursuing this goal by studying the relationship mechanisms of fibrotic remodeling in the adult mammalian lung. My laboratory has had a sustained impact on the field of pulmonary fibrosis and is credited with several seminal discoveries that have been verified and reproduced in laboratories around the world. My early work helped ignite interest in the mechanism(s) through which innate immunity is linked to pulmonary fibrosis. For example, my lab was the first to report that monocytes from patients with Scleroderma associated lung fibrosis adopt profibrotic properties following DAMP stimulation. We reported that the lungs of mice exposed to fibrotic stimuli, and humans with IPF, contain aberrantly activated macrophages that can be repolarized with innate immune agonists to attenuate experimentally induced lung fibrosis. We also are credited with linking intracellular DNA sensors and their ligands with numerous forms of interstitial lung disease. Most recently we reported that a previously unrecognized nerve-lung connection drives mammalian lung fibrosis. My work has been published in journals such as Science, Science Translational Medicine, Nature Medicine, Cell, Journal of Clinical Investigation, Lancet Respiratory Medicine, and the American Journal of Respiratory and Critical Care Medicine. I have been a continuous recipient of NIH funding since 2005 in the form of K08, R01 and U01 awards, and have been honored by my peers with the Jo Rae Wright Award from the American Thoracic Society and induction into the American Society of Clinical Investigation (ASCI). My discoveries in these domains have been informed by collaborations with Yale immunologists, neuroscientists, and bioengineers with the goal of developing new ways to improve respiratory health.
研究兴趣
论文共 214 篇作者统计合作学者相似作者
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Jooyoung Kim,Yifan Yuan, Karen Agaronyan,Amy Zhao, Victoria D Wang,Gayatri Gupta, Heran Essayas, Ayelet Kaminski, John McGovern, Sheeline Yu,Samuel Woo, Chris J Lee,
bioRxiv : the preprint server for biology (2024)
Alexander Ghincea,Carrighan Perry,Angela Liu, John McGovern, Sheeline Yu,Xue Yan Peng,Ishikawa Genta,Thomas Barnthaler,Erica Herzog,Huanxing Sun
biorxiv(2024)
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Amanda S. Pellowe, Michelle J. Wu,Tae-Yun Kang, Tracy D. Chung, Adrian Ledesma-Mendoza,Erica Herzog,Andre Levchenko,Ian Odell,John Varga,Anjelica L. Gonzalez
The American Journal of Pathology (2024)
biorxiv(2024)
Elif Çakan,Marie Dominique Ah Kioon,Yolanda Garcia-Carmona,Salomé Glauzy,David Oliver,Natsuko Yamakawa, Andrea Vega Loza,Yong Du,Jean-Nicolas Schickel,Joshua M Boeckers,Chao Yang, Alessia Baldo,
The Journal of experimental medicineno. 12 (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Chang-Min Lee,Chuan-Hua He,Jin Wook Park, Jae Hyun Lee,Suchitra Kamle,Bing Ma,Bedia Akosman, Roberto Cotez,Emily Chen,Yang Zhou,Erica L. Herzog,Changwan Ryu,
Vitória Fiorini,Buqu Hu, Ying Sun, Sheeline Yu, John McGovern,Shifa Gandhi,Samuel Woo, Sara Jean Turcotte-Foster,Taylor Pivarnik, Zara Khan,Taylor Adams,Erica Herzog,
Chest (2023)
npj Regenerative Medicineno. 1 (2023): 1-18
Genta Ishikawa,Xueyan Peng, John McGovern, Sam Woo,Carrighan Perry,Angela Liu, Sheeline Yu,Alexander Ghincea, Aliaksandr Kishchanka,Vitória Fiorini,Buqu Hu, Ying Sun,
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGYno. 5 (2023): L639-L651
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