基本信息
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职业迁徙
个人简介
The laboratory is currently investigating methods of augmenting immune responses against cancer in the setting of allogeneic bone marrow transplantation, or alloBMT. In alloBMT, the host’s immune system is destroyed by radiation therapy and is replaced by an immune system from a healthy donor. Alloreactive donor T cells recognize host cancer cells as “foreign” and destroy them, but also cause graft-versus-host disease (GVHD), a pathological attack on normal host tissues. We have developed non-toxic methods of inducing donor T cell engraftment without having to destroy the host immune system, and have recently found that tumor “vaccines”, crafted from the host’s tumor cells, can induce potent anti-tumor immunity after alloBMT without causing GVHD. We are currently employing tumors expressing defined antigens and tumor-specific transgenic T cells, which can be tracked in animals undergoing alloBMT. This model will be used to investigate the relative contributions of host versus donor, CD4+ versus CD8+, and alloreactive versus tumor-specific T cells in the eradication of malignancy following alloBMT.
研究兴趣
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Tushar D. Nichakawade, Jiaxin Ge,Brian J. Mog, Bum Seok Lee, Alexander H. Pearlman,Michael S. Hwang,Sarah R. DiNapoli,Nicolas Wyhs, Nikita Marcou,Stephanie Glavaris,Maximilian F. Konig,Sandra B. Gabelli,
Natureno. 8007 (2024): 1-8
Scott D. Ramsey,Aasthaa Bansal, Lily Li, Paul V. O'Donnell,Ephraim J. Fuchs,Claudio G. Brunstein,Mary Eapen,Viengneesee Thao,Joshua A. Roth,Lotte M.G. Steuten
Haval Norman, Timothy Porter,Jamie Elsner Ziggas,Javier Bolaños-Meade,Leo Luznik,Amy E. DeZern,Ephraim J. Fuchs,Richard J Jones
Transplantation and Cellular Therapyno. 2 (2023): S97-S97
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BLOOD (2023)
Blood (2023): 3582
Cole Harris Sterling, Michael Sang Hughes,Hua-Ling Tsai,Ephraim Joseph Fuchs,Kathryn Yarkony,Ravi Varadhan,Douglas Edward Gladstone,Lode J. Swinnen,Richard J. Jones,Nina D. Wagner-Johnston,Richard F. Ambinder
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