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We explore if epigenetics is a hallmark of protein-based inheritance in neurodegeneration. Our research specifically investigates epigenetic mechanisms in human prion diseases. We employ a large array of technologies (transcriptomics, epigenomics, cell-based assays, animal models, patients samples) to determine if, where, when and how epigenetics contribute to disease susceptibility, onset, and progression. Using next-generation technologies we profile DNA, RNA, and histone modifications and identify disease-specific gene (coding and non-coding) signatures and pathways. Some of our current projects also involve machine learning, nanopore sequencing, small molecule inhibitor and genome editing.
Ultimately, our research aims to uncover protein-based inheritance signatures that could be manipulated through drugs and/or lifestyle changes.
Ultimately, our research aims to uncover protein-based inheritance signatures that could be manipulated through drugs and/or lifestyle changes.
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论文共 54 篇作者统计合作学者相似作者
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Emma Jones, Elizabeth Hill,Jacqueline Linehan, Tamsin Nazari,Adam Caulder,Gemma F. Codner,Marie Hutchison,Matthew Mackenzie,Michael Farmer,Thomas Coysh, Michael Wiggins De Oliveira,Huda Al-Doujaily,
NEUROBIOLOGY OF DISEASE (2024): 106363-106363
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
Debby M.E.I. Hellebrekers,Karolien Castermans,Emmanuelle Viré,Ruud P.M. Dings, Nicole T.H. Hoebers,Kevin H. Mayo,Mirjam G.A. oude Egbrink, Grietje Molema,François Fuks,Manon van Engeland,Arjan W. Griffioen
crossref(2023)
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
Emma Jones, Elizabeth Hill,Jacqueline Linehan, Tamsin Nazari,Adam Caulder,Gemma F Codner,Marie Hutchison,Matthew Mackenzie, Michael Wiggins De Oliveira,Huda Al-Doujaily,Malin Sandberg,Emmanuelle Vire,
crossref(2023)
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
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