基本信息
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职业迁徙
个人简介
He provided seminal contributions in the characterization of phosphoinositide 3-kinases (PI3K) asdrug targets in cancer (Science Signaling 2008, Cancer Cell 2011, 2014, 2017), inflammation(Science 2000, Immunity 2002), heart failure (Cell 2004, Circulation 2011 and 2012), and obesity(Science Signaling 2014). He produced the first knockout mice for a PI3K catalytic subunit anddemonstrated the role of PI3Kgamma in chemotaxis of leukocytes (Science 2000; PNAS 2007,Blood 2012). He collaborated with Merck-Serono in the characterization of the first isoformselective PI3Kgamma inhibitor (Nat Med 2005) and launched an academic spin off (Kither Biotechsrl) exploiting his patented PI3K inhibitors for topical treatment. He was the first to demonstratethat PI3K are not only enzymes but also scaffold proteins (Cell 2004, Sci Transl Med 2022),showing that knock-in of a catalytically inactive mutant better models drug targeting than knock-out-mediated elimination of the protein. He demonstrated that PI3Kbeta has scaffold functions (SciSignal 2008) and that PI3Kgamma associates with PKA to integrate PI3K and cAMP signaling(Cell 2004; Mol Cell 2011; Circulation 2012). Lately, he focused his attention to class II PI3Ks anddefined the role of PI3KC2alpha in endocytosis (Nature 2013) and primary cilium function (DevCell 2014; JASN 2015; Nat Com 2015). His work on the role of PI3KC2alpha in breast cancer opened a new way to precisely predict sensitivity to Taxane-based therapies, a mainstay intreatment but with so far variable and erratic efficacy (Cancer Cell, 2017). More recently, hereported that PI3KC2alpha is key to cytokinesis and protects against senescence and catarct(Science 2021).
研究兴趣
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Mouin Nasr, Alexis Fay,Adrien Lupieri,Nicole Malet, Anne Darmon,Rana Zahreddine,Audrey Swiader,Amandine Wahart,Julien Viaud,Anne Negre-Salvayre,Emilio Hirsch, Daniel Monteyne,
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYno. 3 (2024): 620-634
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Arteriosclerosis, thrombosis, and vascular biologyno. 3 (2023): 620-634
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Journal of Cystic Fibrosis (2023): S44-S44
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