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个人简介
My research program is part of the UCLA Center for Neurobiology of Stress (www.uclacns.org) which comprises a wide range of basic and translational research programs under the general theme of stress, pain and emotion. These programs range from cellular and molecular studies into the transduction, transmission and modulation of pain, in the molecular mechanisms of the central stress response, to human studies into brain, autonomic and neuroendocrine responses to emotional and pain stimuli. My personal research interest is focused on identifying and characterizing brain circuits concerned with the encoding and modulation of pain and emotional stimuli in health and in various patient populations with chronic idiopathic pain syndromes, such as irritable bowel syndrome, fibromyalgia and interstititial cystitis. Using a wide range of investigative techniques (fMRI, PET, ERP, connectivity modeling, genetic imaging and pharmacologic imaging) our group aims to identify the role of genetic and environmental factors (including early life events) on the responsiveness of arousal and pain modulation circuits, identify possible alterations in specific signaling systems within these circuits (NK1, CRF1 and D2/D3 receptors) and identify structural differences with affected brain regions. We are correlating these brain circuit alterations with alterations in perception and in autonomic responses to various stimuli. Imaging studies are performed both in human subjects and rodents. We are applying similar investigative techniques to identify the biological underpinnings of pharmacological and mind based therapies for chronic idiopathic pain disorders.
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NEUROGASTROENTEROLOGY AND MOTILITYno. 2 (2024): e14710-e14710
Fiona C. Ross, Dylan E. Mayer,Arpana Gupta, Chris I.R. Gill,Daniele Del Rio,John F. Cryan,Aonghus Lavelle,R. Paul Ross,Catherine Stanton,Emeran A. Mayer
Biological psychiatryno. 4 (2024): 348-360
Vadim Osadchiy, Roshan Bal,Emeran A. Mayer, Rama Kunapuli,Tien Dong,Priten Vora, Danny Petrasek,Cathy Liu,Jean Stains,Arpana Gupta
Biological psychiatryno. 5 (2023): 473-481
Communications medicineno. 1 (2023): 122-8
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