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个人简介
Our laboratory focuses on the molecular mechanisms that govern inflammasome assembly and activity, and the signaling pathways that modulate activation of caspases during cell death and inflammation using in vitro and whole animal model systems. In the past two decades our group was among the leading groups that contributed to the elucidation of the molecular pathways of apoptosis and inflammatory cell death (pyroptosis). We led the initial discovery of several apoptotic caspases, including caspase-3 (CPP32), caspase-9 (Mch6) and caspase-8 (Mch5), and the characterization of the mechanism of activation of the Apaf-1 apoptosome. We have also characterized through a series of high impact publications the role of the mitochondrial serine protease HtrA2/Omi in apoptosis and neurodegeneration, with the most recent work in mice implicating HtrA2/Omi in aging. We have also been investigating the role of NOD-like receptors (NLRs) and non-NLR proteins in activation of caspase-1 in inflammatory cell death, inflammatory diseases and infection. This work led to the discovery of the Ipaf (NLRC4), pyrin, and AIM2 inflammasomes, and the ASC pyroptosome. Our recent work in AIM2-deficient mice demonstrated that AIM2 is uniquely involved in sensing cytosolic DNA released during infection with the intracellular bacteria Francisella tularensis and DNA viruses.
研究兴趣
论文共 245 篇作者统计合作学者相似作者
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Hong Wang, Jiang Xu,Keiko Yasumatsu, Masafumi Jotaki,Cailu Lin, Akihito Kuboki,Liquan Huang,Emad Alnemri,Yuzo Ninomiya,Peihua Jiang,Danielle R. Reed,Robert F. Margolskee
CHEMICAL SENSES (2023)
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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Cell death and differentiationno. 5 (2023): 1097-1154
Dan A. Erkes,Weijia Cai, Ileine M. Sanchez,Timothy J. Purwin,Corey Rogers,Conroy O. Field,Adam C. Berger,Edward J. Hartsough,Ulrich Rodeck,Emad S. Alnemri,Andrew E. Aplin
crossref(2023)
Molecular cancer research : MCRno. 12 (2022): 1811-1821
A. Alnemri,S. Wang,M. Wang, M. Domingo-Vidal, A. Linnenbach, U. Martinez-Outschoorn,T. F. Alnemri,E. S. Alnemri,J. M. Curry
Circulation Researchno. Suppl_1 (2022)
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