基本信息
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职业迁徙
个人简介
Our laboratory studies how signalling networks are regulated by ubiquitin. We use structural biology, enzymology and biochemical and biophysical assays to elucidate the mechanism by which multi-subunit deubiquitylases (DUBs) function.
We identified the metabolic enzyme SHMT2 as the first endogenous inhibitor of DUB activity. We also showed that SHMT2 and vitamin B6 regulate interferon receptor degradation, thus impacting interferon signalling and inflammation.
We also dedicate a major effort in identifying DUB inhibitors as tool compounds to understand biological function and as potential leads for future therapeutics.
Current major projects
Understanding DUB selectivity and their physiological regulation
Understanding DUB allosteric activation
Identification of DUB inhibitors as chemical biology tools and potential therapeutics
We identified the metabolic enzyme SHMT2 as the first endogenous inhibitor of DUB activity. We also showed that SHMT2 and vitamin B6 regulate interferon receptor degradation, thus impacting interferon signalling and inflammation.
We also dedicate a major effort in identifying DUB inhibitors as tool compounds to understand biological function and as potential leads for future therapeutics.
Current major projects
Understanding DUB selectivity and their physiological regulation
Understanding DUB allosteric activation
Identification of DUB inhibitors as chemical biology tools and potential therapeutics
研究兴趣
论文共 39 篇作者统计合作学者相似作者
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Vidhya Krishnamoorthy,Martina Foglizzo,Robert L. Dilley, Angela Wu,Arindam Datta, Parul Dutta, Lisa J. Campbell, Oksana Degtjarik, Laura J. Musgrove,Antonio N. Calabrese,Elton Zeqiraj,Roger A. Greenberg
Cell (2024)
Linda Makhlouf,Joshua J. Peter,Helge M. Magnussen, Rohan Thakur,David Millrine,Thomas C. Minshull, Grace Harrison,Joby Varghese,Frederic Lamoliatte,Martina Foglizzo,Thomas Macartney,Antonio N. Calabrese,
RHEUMATOLOGYno. Supplement_2 (2023)
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Research Square (Research Square) (2023)
ARTHRITIS & RHEUMATOLOGY (2022): 2305-2306
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Nature Communicationsno. 1 (2022): 1-14
Francesca Chandler,Miriam Walden,Poli Adi Narayana Reddy,Joel Cassel, Lillie Bell, Lisa Campbell,Martina Foglizzo,Frank Sicheri,Joseph M Salvino,Roger A Greenberg,Elton Zeqiraj
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