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Epstein-Barr Virus was discovered in human cancer cells in 1964 and was subsequently shown to cause malignant lymphocyte proliferation. With a small group of graduate students and post-doctoral colleagues, I set out to characterize the virus and the biochemical processes by which the virus alters cell growth. Using a combination of genetic and biochemical approaches, we found that the virus encodes four nuclear proteins and a membrane protein, which usurp control over two pathways of normal cell growth and differentiation. The four viral nuclear proteins effect one cell growth regulatory pathway by changing the activity of a cell protein that binds to specific DNA sites and controls the expression of neighboring genes. The virus uses the same strategy to regulate its own genes in infected cells. The virus encoded membrane protein effects a second pathway by mimicking an activated receptor of a type that is particularly important in normal lymphocyte growth regulation. Since infected cell growth is dependent on the viral encoded proteins, the infected tumor cells are susceptible to immunedestruction. These studies are important for understanding normal lymphocyte growth and differentiation, for immune prevention and control of virus associated tumors, and for therapeutic approaches to virus associated malignancies. The latter include Nasopharyngeal Carcinoma, Hodgkin's Disease, and lymphomas, particularly lymphomas in AIDS patients.
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Hua Zhang,Yan Li,Hong-Bo Wang,Ao Zhang, Mei-Ling Chen,Zhi-Xin Fang, Xiao-Dong Dong, Shi-Bing Li,Yong Du,Dan Xiong,Jiang-Yi He, Man-Zhi Li,
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