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Dr. Karlson is a population scientist focusing on the epidemiology and outcomes of rheumatic disease. Her research is focused on epidemiology and outcomes of rheumatic diseases, in particular Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The group has developed innovative epidemiologic tools for testing hypotheses in populations, investigated the epidemiology of rheumatic diseases in large cohorts of female health professionals, studied predictors of outcome in RA and SLE and established a large SLE Registry.
The BWH Rheumatic Disease Epidemiology Group has developed epidemiologic tools for rheumatic disease studies such as the Connective Tissue Disease Screening Questionnaire (CSQ) and demonstrated the validity of a new criteria system for defining SLE cases in research studies. In addition the group developed and validated the Systemic Lupus Activity Questionnaire (SLAQ). This is a tool used to follow SLE patients in outcome studies.
Dr. Karlson and colleagues have studied the epidemiology of rheumatic diseases in prospective cohorts. The investigators demonstrated that postmenopausal hormones and prior oral contraceptive use increased a woman’s risk of SLE, while hair dye use did not increase risk. They also demonstrated through both the Nurses’ Health Study and Women’s Health Cohort Study that breast implants were not associated with clinically significant immunologic abnormalities. They demonstrated that obesity early in life is an important risk factor for osteoarthritis of the hip and that breastfeeding may protect against RA but that coffee, decaffeinated coffee and tea intake were not associated with RA. In recent work, the group has demonstrated associations between cigarette smoking and RA and SLE, occupational silica exposure and SLE, reproductive factors and SLE, antioxidants and RA and gene-environment interactions between GST genes and residential exposure to toxic waste sites and SLE. Additionally, the group showed that RA patients are at increased risk for cardiovascular disease (CVD), have higher inflammatory markers associated with CVD, but receive less cardiovascular preventive care than women without RA. Recent studies include hormonal, cytokine and genetic biomarkers, perinatal risk factors, dietary factors and RA risk; and reproductive factors, silica, and solvents in SLE. I studied gene-environment interactions in SLE and in RA. Current studies include a NIAMS Center project on air pollution and gene-environment interactions in RA risk and an NIH-R01 grant on predictive modeling in RA using genetic and environmental risk factors.
The BWH Rheumatic Disease Epidemiology Group has developed epidemiologic tools for rheumatic disease studies such as the Connective Tissue Disease Screening Questionnaire (CSQ) and demonstrated the validity of a new criteria system for defining SLE cases in research studies. In addition the group developed and validated the Systemic Lupus Activity Questionnaire (SLAQ). This is a tool used to follow SLE patients in outcome studies.
Dr. Karlson and colleagues have studied the epidemiology of rheumatic diseases in prospective cohorts. The investigators demonstrated that postmenopausal hormones and prior oral contraceptive use increased a woman’s risk of SLE, while hair dye use did not increase risk. They also demonstrated through both the Nurses’ Health Study and Women’s Health Cohort Study that breast implants were not associated with clinically significant immunologic abnormalities. They demonstrated that obesity early in life is an important risk factor for osteoarthritis of the hip and that breastfeeding may protect against RA but that coffee, decaffeinated coffee and tea intake were not associated with RA. In recent work, the group has demonstrated associations between cigarette smoking and RA and SLE, occupational silica exposure and SLE, reproductive factors and SLE, antioxidants and RA and gene-environment interactions between GST genes and residential exposure to toxic waste sites and SLE. Additionally, the group showed that RA patients are at increased risk for cardiovascular disease (CVD), have higher inflammatory markers associated with CVD, but receive less cardiovascular preventive care than women without RA. Recent studies include hormonal, cytokine and genetic biomarkers, perinatal risk factors, dietary factors and RA risk; and reproductive factors, silica, and solvents in SLE. I studied gene-environment interactions in SLE and in RA. Current studies include a NIAMS Center project on air pollution and gene-environment interactions in RA risk and an NIH-R01 grant on predictive modeling in RA using genetic and environmental risk factors.
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Psychological Medicineno. 15 (2023): 7435-7445
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PloS oneno. 6 (2023): e0286297-e0286297
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Scientific Reportsno. 1 (2023): 1-1
medRxiv : the preprint server for health sciences (2023)
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