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Our research is leading to the development of more sustainable, environmentally friendly, chemical processes to accelerate drug development and improve the safety of medicines. Our studies into the evolution of catalytic promiscuity in P450s reveal how organisms have evolved to deal with chemicals in the environment and provide insights as to how enzymes develop novel functions. More broadly, the methods that we have developed with colleagues at UQ and in industry for the ancestral reconstruction of P450s and their implementation as sophisticated biocatalysts in industry can be applied to the optimisation of other proteins and enzymes for biotechnological application.
Our research is leading to the development of more sustainable, environmentally friendly, chemical processes to accelerate drug development and improve the safety of medicines. Our studies into the evolution of catalytic promiscuity in P450s reveal how organisms have evolved to deal with chemicals in the environment and provide insights as to how enzymes develop novel functions. More broadly, the methods that we have developed with colleagues at UQ and in industry for the ancestral reconstruction of P450s and their implementation as sophisticated biocatalysts in industry can be applied to the optimisation of other proteins and enzymes for biotechnological application.
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论文共 105 篇作者统计合作学者相似作者
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Bethan S. Jones,Connie M. Ross,Gabriel Foley, Nadiia Pozhydaieva, Joseph W. Sharratt, Nico Kress,Lisa S. Seibt,Raine E. S. Thomson,Yosephine Gumulya,Martin A. Hayes,Elizabeth M. J. Gillam, Sabine L. Flitsch
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 18 (2024): e202314869-e202314869
Ulrik Jurva,Ann-Sofie Sandinge,Jong Min Baek, Mickaël Avanthay,Raine E S Thomson, Stephlina A D'Cunha,Shalini Andersson,Martin A Hayes,Elizabeth M J Gillam
Drug metabolism and disposition: the biological fate of chemicalsno. 3 (2024): 242-251
Bernadius Agustinus,Elizabeth M J Gillam
Journal of inorganic biochemistry (2023): 112242
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Advances in pharmacology (San Diego, Calif.) (2022): 195-252
Philip Hartz, Silja J. Strohmaier, Basma M. EL‐Gayar, Ammar Abdulmughni, Michael C. Hutter, Frank Hannemann, Elizabeth M. J. Gillam, Rita Bernhardt
crossref(2021)
biorxiv(2020)
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