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My research has had two primary focuses: 1) regulation of the synthesis and action of aldosterone, cortisol and corticosterone and 2) the biology of the mineralocorticoid receptor (MR), including its role in pathological cardiovascular remodeling and hypertension and in hemodynamic control centers in the brain, and mechanisms for MR ligand specificity, reviewed in(1, 2). To this end I use a variety of techniques in in vivo physiology and pharmacology, cell culture, biochemistry, molecular biology, and histology. My work has focused on MR action in PVN, yet MR are most abundant in the hippocampus, where they mediate normal affect and cognition and are crucial for neuronal health. Depression, dementia and cardiovascular diseases are independent risk factors for each other. My recent move to a full time position in the Department of Pharmacology & Toxicology greatly facilitates collaborations with others in basic sciences. My association with the Departments of Neurobiology & Anatomical Sciences and Psychiatry through the interdepartmental Program in Neurosciences, provides an opportunity to acquire behavioral and neurobiological expertise to focus on the interface between cardiovascular and neurocognitive diseases. Among techniques used are behavioral, pharmacological and physiological studies in animals, biochemistry and molecular biology, and histopathology and immunohistochemistry.
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The Journal of steroid biochemistry and molecular biology (2023): 106291-106291
Journal of the Endocrine Societyno. Supplement_1 (2022)
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Celso E. Gomez-Sanchez, Dina R. Sapiro, Katie V. May,William E. Rainey,Koshiro Nishimoto,Elise P. Gomez-Sanchez
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