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In the 1960s, Dr. Berson discovered that Electroretinography (ERG) could detect photoreceptor dysfunction up to a decade before vision starts to deteriorate in retinitis pigmentosa; since then, ERG has been used routinely to diagnose this condition and estimate visual prognoses. His further investigations showed that nutritional supplementation with Vitamin A, omega-3, and lutein can slow associated visual field loss.
In the early 1990s, Dr. Berson and his colleague Thaddeus Dryja, MD, discovered the first gene defects associated with retinitis pigmentosa, building on their initial discovery to identify approximately 20 such gene defects. Consequently, numerous biochemical pathways have become avenues for further research in the field, including his collaborations in developing animal models that provided proof-of-concept that gene replacement therapy is feasible for certain retinal degenerations.
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JAMA OPHTHALMOLOGYno. 5 (2018): 490.0-495
B S Pawlyk, O V Bulgakov, X Sun, M Adamian, X Shu,A J Smith,E L Berson,R R Ali, S Khani,A F Wright,M A Sandberg,T Li
Gene Therapyno. 2 (2015): 196-204
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