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Ekwall’s current research is focused on characterizing the function of SNF2 chromatin remodeling factors in epigenetic control and in nuclear organization. His team has determined the mechanistic in vivo and in vitro functions for Chd1 in nucleosome disassembly and spacing (EMBO J 2007; 2012). Chd1 is a key chromatin remodeler, recently implicated in mouse stem cell maintenance and control of pluripotency. The Ekwall group recently provided evidence for DNA topoisomerases and histone ubiquitination in chromatin regulation (EMBO J 2010; PloS Genetics 2013; Nature Struct Mol Biol 2010, 2014). In recent years Ekwall has also developed clinical aspects of his research. He founded the Swedish Epigenetics network (2007) bridging basic and clinical research in epigenetics in Sweden. Ekwall’s group has investigated epigenetic control of human blood cell differentiation (Blood 2014; Nature 2014) and is just now studying epigenetic changes in leukemia in collaboration with clinical research groups at KI (Blood 2010, 2014; Leukemia 2013).
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Sophia Miliara, Elisabetta Cozzi,Xiangfu Zhong, Isaac Chan,Karl Ekwall,Soeren Lehmann,Andreas Lennartsson,Jiri Bartek,Dimitris C. Kanellis
LEUKEMIAno. 3 (2024): 663-666
CHROMOSOME RESEARCHno. 2 (2023): 1-19
Biomoleculesno. 11 (2023): 1662-1662
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Jonas O. Carlsten,Zsolt Szilagyi,Beidong Liu,Marcela Davila Lopez, Erzsébet Szászi, Ingela Djupedal,Thomas Nyström,Karl Ekwall,Claes M. Gustafsson,Xuefeng Zhu
Molecular and Cellular Biologyno. 7 (2021)
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