基本信息
浏览量:80
职业迁徙
个人简介
Research Abstract
My long-term goal is to improve therapies for patients with gastric and esophageal cancer by defining and targeting the key molecular alterations of these tumors. My research focuses on understanding mechanisms of resistance to targeted therapies in gastroesophageal cancer. Specifically, I study the role of intratumoral genomic heterogeneity in gastroesophageal cancer and the challenges it poses to personalized targeted therapies. To overcome these challenges, I am piloting studies to genomically characterize circulating cell-free DNA as a means to more accurately select therapeutic strategies. In addition, I am using functional biology to understand the mechanisms of de novo resistance to ERBB2-directed therapies in gastroesophageal cancer and develop new combination therapeutic strategies.
My long-term goal is to improve therapies for patients with gastric and esophageal cancer by defining and targeting the key molecular alterations of these tumors. My research focuses on understanding mechanisms of resistance to targeted therapies in gastroesophageal cancer. Specifically, I study the role of intratumoral genomic heterogeneity in gastroesophageal cancer and the challenges it poses to personalized targeted therapies. To overcome these challenges, I am piloting studies to genomically characterize circulating cell-free DNA as a means to more accurately select therapeutic strategies. In addition, I am using functional biology to understand the mechanisms of de novo resistance to ERBB2-directed therapies in gastroesophageal cancer and develop new combination therapeutic strategies.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Simona Corso,Claudio Isella,Sara E. Bellomo, Maria Apicella,Stefania Durando,Cristina Migliore,Stefano Ughetto, Laura D’Errico, Silvia Menegon,Daniel Moya-Rull,Marilisa Cargnelutti,Tânia Capelôa,
crossref(2023)
Springer eBookspp.1693-1712, (2023)
crossref(2023)
Simona Corso,Claudio Isella,Sara E. Bellomo, Maria Apicella,Stefania Durando,Cristina Migliore,Stefano Ughetto, Laura D’Errico, Silvia Menegon,Daniel Moya-Rull,Marilisa Cargnelutti,Tânia Capelôa,
crossref(2023)
Leonie K de Klerk,Anuj K Patel,Sarah Derks,Eirini Pectasides,Jeremy Augustin,Mohamed Uduman, Nihal Raman, Fahire G Akarca,Nadine J McCleary,James M Cleary,Douglas A Rubinson,Jeffrey W Clark,
Joseph Elan Grossman,Andrea J. Bullock, Susana Angarita,Bruno Bockorny,Farshid Dayyani, Molly Hurley, Kimberly McGregor,Eirini Pectasides,Mary Linton Bounetheau Peters,Venkataprasanth P. Reddy,Benjamin L. Schlechter, Mehrad Tavallai,
Eirini Pectasides,Ioannis Chatzidakis,Vassiliki Kotoula,Georgia-Angeliki Koliou,Kyriaki Papadopoulou,Eleni Giannoulatou, Vasilios G. Giannouzakos,Mattheos Bobos, Christos Papavasileiou,Sofia Chrisafi, Aikaterini Florou,Dimitrios Pectasides,
CANCER GENOMICS & PROTEOMICSno. 3 (2020)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn