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Research Interest Statement
Eileen White’s laboratory focuses on identifying mechanisms required for tumor cells and tumors to survive, proliferate, and evade surveillance by the immune system. The overall goal is to reveal novel approaches for cancer therapy. By studying how an oncogene encoded by the DNA tumor virus adenovirus promotes oncogenesis they established that it encoded a viral homologue of the human BCL-2 oncoprotein that blocked apoptosis by binding and inhibiting pro-apoptotic BCL-2 protein family members. These findings contributed to the intellectual leap that evading apoptosis was one of the hallmarks of cancer. By examining how tumor cells survive nutrient deprivation they discovered that they do so by upregulating intracellular nutrient scavenging by autophagy to recycle macromolecules into metabolic pathways. They went on to establish that autophagy in the host sustains levels of the amino acid arginine in the circulation, which is essential for tumor growth. By examining how autophagy controls the immune response they discovered that autophagy suppresses inflammation, thereby limiting an anti-tumor T-cell response that enables tumor growth. Collectively, these findings delineated novel tumor cell autonomous and host metabolic functions maintained by autophagy critical for tumor growth, and the means by which autophagy prevents tumor elimination by the immune system.
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Xue Yang,Jianming Wang,Chun-Yuan Chang,Fan Zhou,Juan Liu,Huiting Xu,Maria Ibrahim, Maria Gomez,Grace L. Guo, Hao Liu,Wei-Xing Zong,Fredric E. Wondisford,
Nature Communicationsno. 1 (2024): 1-15
Cold Spring Harbor perspectives in medicine (2024)
Sarah Cherkaoui,Lifeng Yang,Matthew McBride, Christina S Turn,Wenyun Lu, Caroline Eigenmann,George E Allen,Olesya O Panasenko, Lu Zhang,Annette Vu,Kangning Liu,Yimei Li,
bioRxiv : the preprint server for biology (2024)
Cristina M. Karp, Ting Ting Tan,Robin Mathew, Deidre Nelson, Chandreyee Mukherjee,Kurt Degenhardt, Vassiliki Karantza-Wadsworth,Eileen White
crossref(2023)
Henning Tim Langer,Shakti Ramsamooj,Ezequiel Dantas,Anirudh Murthy, Mujmmail Ahmed,Seo-Kyoung Hwang,Rahul Grover, Rita Pozovskiy,Roger J. Liang,Andre Lima Queiroz,Justin C Brown,Eileen P. White,
biorxiv(2023)
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CANCER RESEARCHno. 7 (2023)
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Cell death & diseaseno. 1 (2023): 61-14
Cristina M. Karp, Ting Ting Tan,Robin Mathew, Deidre Nelson, Chandreyee Mukherjee,Kurt Degenhardt, Vassiliki Karantza-Wadsworth,Eileen White
crossref(2023)
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