Edwin R. Speck

Senior Research Assistant, Canadian Blood Services, Research and Development, Toronto, Ontario, Canada.

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Papers31 papers

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Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP).

Rick Kapur,Rukhsana Aslam,Edwin R Speck,Johan M Rebetz,John W Semple

Platelets, pp.1-4, (2019)

WOSBibtex

Anti-platelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia (ITP).

L Guo,R Kapur,R Aslam, K Hunt, Y Hou, A Zufferey,E R Speck,M T Rondina,A H Lazarus,H Ni,J W Semple

Scandinavian journal of immunology, (2018)

WOSBibtex

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury.

Rick Kapur,Michael Kim,Johan Rebetz,Björn Hallström, Jonas T Björkman, Alisa Takabe-French, Noel Kim, Jonathan Liu, Shanjeevan Shanmugabhavananthan, Stefan Milosevic,Mark J McVey,Edwin R Speck

Blood advances, no. 13 (2018): 1651-1663

Cited by2WOSBibtex

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

Rick Kapur, Michelle D Catalina,Rukhsana Aslam,Edwin R Speck, Richard F Francovitch,John W Semple

British journal of haematology, (2017)

Cited by2WOSBibtex

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Anne Zufferey,Edwin R Speck,Kellie R Machlus,Rukhsana Aslam,Li Guo,Mark J McVey,Michael Kim,Rick Kapur,Eric Boilard,Joseph E Italiano,John W Semple

Blood advances, no. 20 (2017): 1773-1785

Cited by5WOSBibtex

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Rick Kapur,Rick Kapur,Michael Kim,Rukhsana Aslam,Mark J. McVey,Arata Tabuchi, Jonathan Liu, Yuan Li, Yuan Li, Shanjeevan Shanmugabhavananthan,Edwin R. Speck, Anne Zufferey

Blood, no. 18 (2017): 2557-2569

Cited by16Bibtex

DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

Hajera Amatullah,Yuexin Shan,Brittany L Beauchamp,Patricia L Gali, Sahil Gupta,Tatiana Maron-Gutierrez,Edwin R Speck,Alison E Fox-Robichaud,Jennifer L Y Tsang,Shirley H J Mei,Tak W Mak,Patricia R M Rocco

American journal of respiratory and critical care medicine, no. 7 (2017): 889-905

Cited by14WOSBibtex

Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur,Michael Kim, Shanjee Shanmugabhavananthan, Jonathan Liu, Noel Kim, Stefan Milosevic,Edwin R. Speck,John W. Semple

Blood, no. 22 (2016): 92-92

Bibtex

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

Anne Zufferey,Edwin R. Speck,Li Guo,Rukhsana Aslam,Rick Kapur,John W. Semple

Blood, no. 23 (2015): 3465-3465

Bibtex

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur,Rukhsana Aslam,Edwin R. Speck,Michael Kim, Anne Zufferey,Li Guo,George B. Segel,Heyu Ni,John W. Semple

Blood, no. 23 (2015): 2251-2251

Bibtex

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Rick Kapur,Michael Kim, Shanjee Shanmugabhavananthan,Edwin R. Speck,Rukhsana Aslam,Li Guo, Anne Zufferey,John W. Semple

Blood, no. 23 (2015): 2342-2342

Bibtex

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple,Edwin R. Speck,Rukhsana Aslam,Michael Kim, Anne Zufferey,Heyu Ni, Michelle Catalina, Richard Francovitch

Blood, no. 23 (2015): 1045-1045

Bibtex

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo,Rukhsana Aslam, Yajing Zhao,Edwin R. Speck,Heyu Ni,John W. Semple

Blood, no. 21 (2014): 2785-2785

Bibtex

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

Kristin Hunt,Rukhsana Aslam,Edwin R. Speck,Heyu Ni,Alan H. Lazarus

Blood, no. 21 (2013): 3537-3537

Bibtex

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, Xu Zhang,Yu Hu,Li Guo,Edwin R. Speck,Heyu Ni,Rukhsana Aslam

Blood, no. 21 (2012): 1088-1088

Bibtex

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Li Guo,Rukhsana Aslam,Edwin R Speck,Heyu Ni,Ming Hou,John J. Freedman,John W. Semple

Blood, no. 21 (2010): 3686-3686

Bibtex

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Y L Fung,Michael Kim,Edwin R Speck,John Freedman,John W Semple

Blood, (2009)

Bibtex

Rukhsana Aslam,Edwin R Speck,Michael Kim,John Freedman,John W Semple

Transfusion, no. 9 (2008): 1778-1786

Cited by25WOSBibtex

A novel immunosuppressive pathway involving peroxynitrate-mediated nitration of platelet antigens within antigen-presenting cells

John W. Semple,Edwin R. Speck,Antonio Fabron Jr,Rukhsana Aslam Michael Kim,John Freedman

Transfusion, no. 9 (2008): 1917-1924

Cited by1Bibtex

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study.

Elisabeth Semple,Edwin R Speck,Rukhsana Aslam,Michael Kim,Vijay Kumar,John W Semple

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and..., no. 4 (2008): 632-638

Cited by10WOSEIBibtex

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets.

Mimi Kjaersgaard,Rukhsana Aslam,Michael Kim,Edwin R Speck,John Freedman,Donald I H Stewart,Erik J Wiersma,John W Semple

Blood, no. 4 (2007): 1359-1361

Cited by13WOSBibtex

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Leola Chow,Heyu Ni,Michael Kim,Edwin R. Speck,Rukhsana Aslam,Pingguo Chen,John Freedman,John W. Semple

Blood, no. 11 (2007): 99-99

Bibtex

Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity.

John W. Semple,Rukhsana Aslam,Edwin R. Speck,John Freedman

Blood, no. 11 (2006): 1093-1093

Bibtex

The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis.

John W. Semple,Rukhsana Aslam,Michael Kim,Edwin R. Speck, Donald I.H. Stewart, Erik Weirsma,John Freedman, Mimi Kjaersgaard

Blood, no. 11 (2006): 21-21

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Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-production in vivo

Rukhsana Aslam,Edwin R. Speck,Michael Kim,Andrew R. Crow,K. W. Annie Bang,Frederick P. Nestel,Heyu Ni,Alan H. Lazarus,John Freedman,John W. Semple

Cited by27Bibtex

Nitrosylation of Platelet MHC Class I Molecules Directs Their Movement into the Immunosuppressive MHC Class I Processing Pathway within Antigen Presenting Cells.

John W. Semple,Edwin R. Speck,John Freedman

Blood, no. 11 (2004): 837-837

Bibtex

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.

Ebrahim Sayeh,Rukshana Aslam,Edwin R Speck,Hoang Le-Tien,Alan H Lazarus,John Freedman,John W Semple

Transfusion, no. 11 (2004): 1572-1578

Cited by9WOSBibtex

Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation

John W Semple, D Cosgrave,Edwin R Speck, A Bang,Victor S Blanchette,John Freedman

(1997)

Bibtex

Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.

M J Rapoport,A H Lazarus,A Jaramillo,E Speck,T L Delovitch

The Journal of experimental medicine, no. 4 (1993): 1221-1226

Cited by73WOSBibtex

Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells.

J W Semple,Y Lang,E R Speck,T L Delovitch

International immunology, no. 10 (1992): 1161-1167

Cited by5WOSBibtex

PLATELET AND ERYTHROCYTE PHAGOCYTOSIS KINETICS ARE DIFFERENTIALLY CONTROLLED BY PHOSPHATASE ACTIVITY WITHIN MONONUCLEAR CELLS. a

Rukhsana Aslam,Michael Kim,Edwin R. Speck,Arjuna Contram Seetanah,Steven Molinski,John Freedman,John W. Semple

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