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Dr. V. Reggie Edgerton received his Ph.D. in Exercise Physiology from Michigan State University, Masters from University of Iowa and BS from East Carolina University. He has been a Professor at the University of California, Los Angeles, since 1968. Dr. Edgerton’s laboratory focuses on two main research questions. One question is how do the neural networks in the lumbar spinal cord of mammals, including humans, regain control of standing, stepping and voluntary control of fine movements after paralysis, and how can these motor functions be modified by chronically imposing activity-dependent interventions after spinal cord injury. Limb motion, electromyographic and kinetics data are recorded to assess the quality of movements. These studies have shown that the mammalian spinal cord, without any input from the brain, can learn specific complex motor tasks such as standing and stepping. We have recently observed that electrodes placed epidurally over the lumbosacral spinal cord can be used to neuromodulate the spinal circuitry so that after a complete spinal cord transection, when used in combination with select pharmacological compounds, the rat is capable of performing full weightbearing stepping at different speeds and at different levels of load bearing and can even step in different directions. Thus we now have 3 effective ways to neuromodulate the spinal cord to improve and regain function: tonic stimulation of the spinal circuitry using epidural electrodes, pharmacological compounds and repetitive training of motor tasks. Application of these interventions has made it possible to recover full weightbearing standing and stepping after complete paralysis in the rat. Even more recent experimental data have shown that epidural stimulation alone can enable individuals with complete paralysis for more than 2 years can regain the ability to stand independently and even regain significant levels of voluntary control of movement of the legs. Largely using animal models of complete paralysis we are aggressively developing and testing these interventions in humans, as we are also attempting to determine the mechanisms for this recovery potential.
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论文共 828 篇作者统计合作学者相似作者
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Evgeniy I. Kreydin,Aidin Abedi, Veronica Stefania Montero,Luis Morales,Rita Jen,Laura Perez,Anibal La Riva,Priya Kohli,Charles Y. Liu,David A. Ginsberg,Parag Gad,V. Reggie Edgerton,
Yaejin Moon, Chen Yang, Nicole C. Veit,Kelly A. McKenzie, Jay Kim, Shreya Aalla,Lindsey Yingling, Kristine Buchler, Jasmine Hunt,Sophia Jenz,Sung Yul Shin, Ameen Kishta,
BioMedical Engineering OnLineno. 1 (2024): 1-18
Evgeniy I. Kreydin,Aidin Abedi, Veronica Stefania Montero,Luis Morales,Rita Jen,Laura Perez,Anibal La Riva,Priya Kohli,Charles Y. Liu,David A. Ginsberg,Parag Gad,V. Reggie Edgerton,
JOURNAL OF UROLOGYno. 2 (2024): 304-304
Efren Aldana, James Araiza, Y. Curtis Wang,Hui Zhong,Niranjala Tillakaratne,V. Reggie Edgerton, Michael Joseph
PHYSIOLOGYno. S1 (2023)
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Kreydin E,Montero Arcila V,Morales Ojeda L, Chapman D, Jen R, Kohli P, Ponce S, Ha N, Ginsberg D,Edgerton V,Gad P, Jann K,
Continence (2023): 100949-100949
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Spinal Interneuronspp.343-366, (2023)
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Frontiers in neuroscience (2023): 1221809
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