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Mathematical modelling of dynamic biological phenomena. The group is involved in multi-disciplinary research projects to understand cellular organization, cellular processes, stress response, and decision making. Using yeast Saccharomyces cerevisiae as major model organism, we develop predictive models of various signalling pathways, metabolic pathways, cell cycle and the interaction of such pathways upon environmental changes. They closely collaborate with various experimental groups for iterative modelling and experimentation. The mathematical methods include ordinary and partial differential equations, Boolean and Bayesian networks, deterministic and stochastic simulations as well as various aspects of dynamic systems theory. They also develop computational tools for the processing of such models, including parameter estimation, sensitivity analysis and semantic assignments. Klipp is involved in various initiatives for standardization both of mathematical models and respective experimentation. She is founding member of the International Society of Systems Biology, member of several scientific advisory boards for systems biology consortia (Reactome, RoBust, Crisp), co-organizer of FEBS Advanced Lecture Courses in Systems Biology (2007, 2009), and PI in several European and national research consortia for systems biology.
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论文共 200 篇作者统计合作学者相似作者
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FEMS yeast research (2024)
Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A. Newcombe,Montaña Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina V Ernstsen,Shweta Jain, Alicia Espiña Bou,Annette Eva Langkilde,
The EMBO Journal (2023)
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Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A. Newcombe,Montana Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina Ernstsen,Shweta Jain, Alicia Espina Bou,Annette Eva Langkilde,
EMBO JOURNAL (2023)
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Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A Newcombe,Montaña Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina V Ernstsen,Shweta Jain, Alicia Espiña Bou,Annette Eva Langkilde,
biorxiv(2023)
BMC Bioinform.no. 1 (2023): 246-16
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PLANT CELL AND ENVIRONMENTno. 2 (2022): 464-478
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