基本信息
浏览量:3
职业迁徙
个人简介
This is a broad remit because he believes it is essential to characterise physiological resolving inflammation, in order to understand chronic inflammatory disease. To facilitate studies in this area he utilises sophisticated in vitro models of vascular inflammation, including unique co-culture platforms using human cells. In addition his group have developed pre-clinical models of inflammation and inflammatory disease in which to conduct translational work. His group work under 3 major themes:
The cellular pathology of Athersclerosis: This theme has drawn long term support from the BHF, including 10 years of Personal Fellowship and 5 years of Programme Grant funding. Our recent work investigates the role of platelets in monocyte recruitment during atherogenesis.
Regulation of the inflammatory response by dietary omega-3 polyunsaturated fatty acids (n-3-PUFAs; AKA fish oils): The affects of n-3 PUFAs on endothelial cell and leukocyte biology is my niche area in this field, and we are using our in vitro modelling skills, to identify new steps in the regulation of leukocyte recruitment, differentiation and function.
Regulation of the inflammatory response by a novel peptide derived from the 14.3.3.zeta protein: We have identified an endogenous peptide mediated mechanism by which T cell recruitment is regulated. We believe that this unique pathway may be important in many auto-immune and/or chronic inflammatory diseases in which T cells contribute to the cellular pathology. A University of Birmingham spinout company, Viatem Ltd, is currently translating patents around this area into new anti-inflammatory drugs.
The cellular pathology of Athersclerosis: This theme has drawn long term support from the BHF, including 10 years of Personal Fellowship and 5 years of Programme Grant funding. Our recent work investigates the role of platelets in monocyte recruitment during atherogenesis.
Regulation of the inflammatory response by dietary omega-3 polyunsaturated fatty acids (n-3-PUFAs; AKA fish oils): The affects of n-3 PUFAs on endothelial cell and leukocyte biology is my niche area in this field, and we are using our in vitro modelling skills, to identify new steps in the regulation of leukocyte recruitment, differentiation and function.
Regulation of the inflammatory response by a novel peptide derived from the 14.3.3.zeta protein: We have identified an endogenous peptide mediated mechanism by which T cell recruitment is regulated. We believe that this unique pathway may be important in many auto-immune and/or chronic inflammatory diseases in which T cells contribute to the cellular pathology. A University of Birmingham spinout company, Viatem Ltd, is currently translating patents around this area into new anti-inflammatory drugs.
研究兴趣
论文共 98 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jonathan W. Lewis, Kathryn Frost,Georgiana Neag,Mussarat Wahid, Melissa Finlay, Ellie H. Northall, Oladimeji Abudu, Edward T. Davis, Emily Powell,Charlotte Palmer, Jinsen Lu,G. Ed Rainger,
Cell Reports Medicineno. 5 (2024): 101574-101574
Clinical and experimental immunologyno. 1 (2023): 1-10
Myriam Chimen, Aigli Evryviadou, Clare L Box,Matthew J Harrison,Jon Hazeldine, Lea H Dib,Sahithi J Kuravi,Holly Payne,Joshua M J Price,Dean Kavanagh,Asif J Iqbal,Sian Lax,
Peter J Noy, Rebecca L Gavin,Dario Colombo,Elizabeth J Haining,Jasmeet S Reyat,Holly Payne,Ina Thielmann,Adam B Lokman,Georgiana Neag,Jing Yang, Tammy Lloyd,Neale Harrison,
Blood Advancesno. 3 (2019): 275-287
Alessandra Borgognone,Eduard Shantsila, Sophie M Worrall,Eakkapote Prompunt,Thomas Loka,Brodie L Loudon,Myriam Chimen,G Ed Rainger,Janet M Lord, Ashley Turner,Peter Nightingale,Martin Feelisch,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn